Neuromuscular mechanisms of primary peristalsis

The American Journal of Medicine
N E Diamant

Abstract

Primary peristalsis of the esophagus is initiated by the act of swallowing. Control of the orderly contraction must take into account coordination of the activity in the esophageal body with the sphincters at either end, integration of activity between the striated and smooth muscle portions of the esophagus, and the central and peripheral neural and muscular control mechanisms present. Peristalsis in the striated section is directed by sequential vagal excitation arising in a brainstem "Central Program Generator." Peristalsis in the smooth muscle section involves the interaction of central and peripheral neural mechanisms and probably the interaction between these neural mechanisms and smooth muscle properties. Coordination of activity between the striated and smooth muscle portions has similar multifaceted neural and mechanical components. In the smooth muscle, 2 main neural mechanisms, a cholinergic excitatory one and a nonadrenergic, noncholinergic (NANC) inhibitory one interact together and with central and local influences to regulate the amplitude, velocity, and direction of propagation of the peristaltic contraction.

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Citations

Sep 29, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·X ZhangD A Sifrim
May 1, 2010·Cell and Tissue Research·Goran RadenkovicOlivera Mitrovic
Feb 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R TutuianD O Castell
Feb 24, 1999·Journal of Gastroenterology and Hepatology·H Badriul, Y Vandenplas
Jan 16, 2003·The American Journal of Gastroenterology·Eliza Maria BritoDonald O Castell
Jun 27, 2006·Journal of Gastroenterology·Toku Takahashi
Jan 29, 2009·The American Journal of Gastroenterology·Alankar GuptaSudarshan R Jadcherla
Jan 11, 2008·The American Journal of Gastroenterology·James S ScolapioMohammed A Qadeer
Feb 22, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ivan M LangReza Shaker
Jul 15, 2015·The Journal of Pastoral Care & Counseling : JPCC·Steven Ballaban
Nov 16, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jan D HuizingaNicholas E Diamant

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