PMID: 6534971Dec 1, 1984Paper

Neuromuscular plasticity following limb immobilization

Journal of Neurocytology
B R Pachter, A Eberstein

Abstract

The effects of immobilization on the ultrastructure of the rat neuromuscular junction of type I and type II muscle fibres were studied both qualitatively and quantitatively. Muscle fibre areas were measured as well. The plantaris muscle was immobilized in a shortened position by applying a plaster cast for three weeks. Immobilized muscles were then compared to normal litter mates. Both type I and type II immobilized muscle fibres atrophied. Endplates from type II muscle fibres exhibited greater amounts of degeneration than type I endplates. Degeneration consisted of nerve terminal disruption, exposed junctional folds, postsynaptic areas which contained little or no postjunctional folds, and subjunctional sarcoplasmic masses. In addition to degeneration, the type II endplates also exhibited regeneration in the same endplate consisting of small terminals associated with large expanses of junctional folds, several small terminals occurring within the same primary synaptic cleft, and several axons wrapped by the same Schwann cell. These observations suggest terminal axonal regeneration. Our results demonstrate that limb immobilization produces muscle atrophy as well as denervation-like changes at the neuromuscular junctions which l...Continue Reading

References

Mar 25, 1976·Nature·A PestronkJ W Griffin
Jan 1, 1977·Experimental Aging Research·J RobertsP B Goldberg
Jan 1, 1975·Experimental Neurology·V R EdgertonD R Simpson
Jul 1, 1971·Journal of Neurophysiology·N Robbins, G D Fischbach
Apr 1, 1969·The Journal of Physiology·G D Fischbach, N Robbins
Apr 1, 1983·Experimental Neurology·M FournierV R Edgerton
Jan 1, 1981·Annual Review of Neuroscience·M C BrownW G Hopkins
May 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·F W Booth
Aug 1, 1982·Journal of Neurocytology·M A Fahim, N Robbins
Aug 1, 1960·The Journal of Comparative Neurology·W V COLE

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Citations

Oct 1, 1991·Molecular and Chemical Neuropathology·S RibaricP Kroselj
Jul 16, 2005·The International Journal of Neuroscience·Meredith H Wilson, Michael R Deschenes
May 2, 2006·Progress in Neurobiology·Jonathan R Wolpaw, Jonathan S Carp
Apr 24, 2008·Critical Care Medicine·Heidrun FinkManfred Blobner
May 1, 1989·The Anatomical Record·M A Fahim
Aug 1, 1996·Muscle & Nerve·E A GranaM M Jaweed

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