Neuromuscular stimulation ameliorates ischemia-induced walking impairment in the rat claudication model

The Journal of Physiological Sciences : JPS
Momoko Shiragaki-OgitaniAtsushi Aoyagi

Abstract

Intermittent claudication (IC) is the most common symptom of peripheral arterial disease which significantly deteriorates the quality of life of patients. Exercise training is by far the most effective treatment for IC; however, the underlying mechanisms remain elusive. To determine the local mechanisms by which exercise training improves walking performance in claudicants, we developed an implantable device to locally induce ischemic skeletal muscle contraction mimicking exercise via electrical stimulation (ES). Rats were assigned to four groups, Sham, Ischemia (Isch), Isch + exercise and Isch + ES groups. Following both unilateral femoral and iliac artery occlusion, rats showed sustained impairment of walking performance in the treadmill test. Chronic low-frequency ES of ischemic skeletal muscles for 2 weeks significantly recovered the occlusion-induced walking impairment in the rat claudication model. We further analyzed the ischemic skeletal muscles immunohistochemically following ES or exercise training; both ES and exercise training significantly increased capillaries in the ischemic skeletal muscles and shifted the muscle fibers toward oxidative types. These findings demonstrate that ES takes on common features of exerci...Continue Reading

References

Apr 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·D Sørlie, K Myhre
Jan 1, 1992·Reviews of Physiology, Biochemistry and Pharmacology·D Pette, G Vrbová
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·R ThériaultJ A Simoneau
Aug 14, 1998·Journal of Cardiopulmonary Rehabilitation·J F MaillefertJ P Didier
Nov 7, 2000·The American Journal of Medicine·D L DawsonD E Strandness
Jul 16, 2004·American Journal of Physiology. Cell Physiology·Richard E WatersZhen Yan
Feb 18, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P J AthertonH Wackerhage
Apr 7, 2005·Clinical and Experimental Pharmacology & Physiology·Valerio G BaraunaEdilamar M Oliveira
Jul 16, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·M D BrownO Hudlicka
Aug 19, 2007·The Journal of Biological Chemistry·Christoph HandschinBruce M Spiegelman
Jul 21, 2009·Experimental Physiology·Lisete C Michelini, Javier E Stern
Apr 27, 2010·The Journal of Biological Chemistry·Shamina M RangwalaJudit Markovits
Sep 14, 2011·Journal of Strength and Conditioning Research·Jacob M WilsonJeong-Su Kim
Jan 12, 2012·The Journal of Physiological Sciences : JPS·Fumiko NagatomoAkihiko Ishihara
Nov 28, 2012·Circulation·Nina Mann, Anthony Rosenzweig
May 11, 2013·The Journal of Physiological Sciences : JPS·Kana EndoTakafumi Hamaoka
Apr 18, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ding AnLaurie J Goodyear
Jun 14, 2014·Journal of Physical Therapy Science·Jong Ho Kang, In Hyouk Hyong
Jan 31, 2015·Expert Opinion on Biological Therapy·Fumihiro SanadaRyuichi Morishita
Feb 26, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carole HéniqueIsabelle Cohen
Oct 16, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S M O Peeters WeemF L Moll
Nov 10, 2015·JAMA : the Journal of the American Medical Association·Farzin FakhryM G Myriam Hunink
Feb 3, 2016·Frontiers in Human Neuroscience·Marco TaubertNico Lehmann
Mar 19, 2016·Journal of the American College of Cardiology·Jeffrey W OlinWilliam R Hiatt
Oct 25, 2017·Biochemical Pharmacology·Martin Weihrauch, Christoph Handschin
Feb 23, 2018·Current Opinion in Pharmacology·Vasiliki TsigkouDimitris Tousoulis

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
A S LeichtJ Golledge
Australian Family Physician
Handbook of Non Drug Intervention (HANDI) Project Team
Journal of Cardiopulmonary Rehabilitation
Robert T Eberhardt
© 2021 Meta ULC. All rights reserved