Neuromuscular transmission in migraine: a single-fiber EMG study in clinical subgroups

Neurology
Anna AmbrosiniJ Schoenen

Abstract

To search for impairment of neuromuscular transmission by single-fiber electromyography (SFEMG) in patients with common forms of migraine. P/Q Ca(2+) channels are genetically abnormal in most cases of familial hemiplegic migraine (International Headache Society [IHS] code 1.2.3) and may be involved in other types of migraine. Besides in the brain, these channels are found in motor nerve endings, where they control stimulation-induced acetylcholine release. If they are functionally abnormal, the neuromuscular transmission might be impaired. Sixty-two migraineurs (18 without aura, IHS code 1.1; 19 with typical aura, IHS code 1.2.1; 10 with prolonged aura, IHS code 1.2.2; 15 with and without aura) and 16 healthy control subjects underwent stimulation SFEMG. Results were expressed as the mean value of consecutive differences (MCD) and percentage of single-fiber abnormalities (abnormal jitter or impulse blocking). Average MCD was comparable in control subjects and migraineurs (17.1 +/- 2.6 versus 17.5 +/- 4.7 microsec). By contrast, single-fiber abnormalities were found in 17 patients but in none of the control subjects (p = 0.036). Most of these patients had unilateral sensorimotor symptoms and/or aphasia and/or loss of balance dur...Continue Reading

Citations

Feb 6, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Azize Esra GürsoyMustafa Ertaş
Jan 22, 2009·The Cerebellum·Filippo BrighinaBrigida Fierro
Jun 14, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean SchoenenAlain Maertens de Noordhout
Jul 10, 2003·Lancet Neurology·Anne DucrosMarie-Germaine Bousser
Feb 27, 2003·Cephalalgia : an International Journal of Headache·A AmbrosiniJ Schoenen
Feb 27, 2003·Cephalalgia : an International Journal of Headache·A M J M van den Maagdenberg, J J Plomp
Apr 18, 2003·Cephalalgia : an International Journal of Headache·A AmbrosiniJ Schoenen
Jun 6, 2002·Headache·Peter S SándorJean Schoenen
Nov 11, 2006·Clinical Neuropharmacology·Filippo BrighinaBrigida Fierro
Sep 12, 2007·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Mustafa ErtasBetul Baykan
Aug 24, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J M HansenJ Schoenen
Jun 16, 2005·Cephalalgia : an International Journal of Headache·P S SándorR M Agosti
Sep 16, 2005·Cephalalgia : an International Journal of Headache·I DomitrzH Kwieciñski
Sep 6, 2007·Cephalalgia : an International Journal of Headache·M AllenaA R Bisdorff
Oct 9, 2007·Cephalalgia : an International Journal of Headache·M B BasloM Ertas
Nov 1, 2007·Cephalalgia : an International Journal of Headache·D MagisUNKNOWN EUROHEAD Project
Feb 19, 2008·Cephalalgia : an International Journal of Headache·H BolayA Babacan
May 13, 2003·Clinical Cornerstone·N T Mathew
Jun 5, 2002·Current Opinion in Neurology·Esther E KorsMichel D Ferrari
Sep 23, 2009·Expert Review of Neurotherapeutics·Chad A Whyte, Stewart J Tepper
May 15, 2012·Neurologia i neurochirurgia polska·Izabela DomitrzHubert Kwieciński
Sep 8, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Susan E TomlinsonDavid Burke
Feb 6, 2008·The Journal of Headache and Pain·Anna AmbrosiniJean Schoenen
Jun 6, 2003·Headache·Mustafa Ertas, M Baris Baslo
Jul 27, 2006·Headache·Andreas R Gantenbein, Peter S Sándor
Jul 27, 2006·Headache·Elizabeth LoderBoukje De Vries
May 25, 2013·Headache·Gabriela F CarvalhoDébora Bevilaqua-Grossi
Jun 11, 2003·Physical Medicine and Rehabilitation Clinics of North America·Justina L Tanhehco
Mar 17, 2009·Neuron·Mingshan Xue, Christian Rosenmund
May 1, 2019·The Journal of Headache and Pain·Gianluca CoppolaFrancesco Pierelli
Aug 31, 2019·Headache·Dan Buch, Hugues Chabriat

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