Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome

Multiple Sclerosis : Clinical and Laboratory Research
Lahar R MehtaSteven R Schwid

Abstract

Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous system characterized by severe episodes of optic nerve and spinal cord inflammation. NMO-IgG (anti-aquaporin-4) has been recently described as a sensitive and specific marker for NMO. As there have been prior published reports of an association between NMO and systemic autoimmune diseases, the prognostic value of the antibody test in these cases is uncertain. We describe a 47-year old woman with recurrent transverse myelitis and a long-standing history of systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APLS). While she did not have a history of optic neuritis, serological testing for the NMO-IgG was positive when she was admitted for her second episode of transverse myelitis. Testing for the NMO-IgG in cases of isolated or recurrent transverse myelitis attributed to current SLE and APLS may help clarify the diagnosis of a distinct disease process likely to cause recurrent and severe disability, warranting more aggressive immunotherapy.

References

Oct 1, 1979·Archives of Neurology·E L KinneyL M Fox
Sep 25, 1999·Neurology·D M WingerchukB G Weinshenker
Aug 10, 2005·The Journal of Experimental Medicine·Vanda A LennonShannon R Hinson
Feb 3, 2006·Annals of Neurology·Brian G WeinshenkerVanda A Lennon
May 24, 2006·Neurology·D M WingerchukB G Weinshenker
Feb 9, 2007·Neurology·S JariusA Vincent
Jun 15, 2007·Archives of Neurology·Brian G Weinshenker

❮ Previous
Next ❯

Citations

Jun 10, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J SellnerB Hemmer
May 15, 2013·Journal of Neuroimmunology·Radhika A VaishnavRobert P Friedland
Sep 17, 2011·Current Rheumatology Reports·Emilio Benavente, Sergio Paira
Apr 8, 2014·Neurología : publicación oficial de la Sociedad Española de Neurología·M C Gil AlzuetaM T Cabada Giadás
May 21, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Raja Sawaya, Wael Radwan
Apr 24, 2013·Neuroimaging Clinics of North America·Naila MakhaniManohar Shroff
Jun 26, 2012·Immunological Reviews·Robert C Axtell, Chander Raman
Nov 13, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Anu JacobJerome de Seze
Jun 24, 2014·Rheumatology International·Eduardo Freitas, Joana Guimarães
May 12, 2016·Current Allergy and Asthma Reports·Dominique Rosales, Ilya Kister
Oct 12, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Adi Vaknin-DembinskyDimitrios Karussis
Nov 29, 2012·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Mohsen ForoughipourAli Shoeibi
Oct 17, 2013·Expert Review of Clinical Immunology·Jérome de Seze, Nicolas Collongues
May 23, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yulei HaoJiachun Feng
Jan 25, 2020·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Raed AlroughaniEslam Shosha
Dec 17, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Rolando CimazRenzo Guerrini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.