PMID: 9421139Jan 8, 1998Paper

Neuron addition during growth of the postmetamorphic bullfrog: sensory neuron and axon number

The Journal of Comparative Neurology
M L Meeker, P B Farel

Abstract

Neuron addition is one means whereby the nervous system can compensate for increased body size. Neurons can be added either by mitosis of stem cells or by late differentiation of committed precursors. Previously, the doubling of hind limb dorsal root ganglion (DRG) neurons in postmetamorphic bullfrogs (Rana catesbeiana) was found to occur in the absence of neuron proliferation (St. Wecker and Farel [1994] J. Comp. Neurol. 342:430-438). In the present study, we identify a population of cells in the DRGs of juvenile frogs that lack the appearance typical of sensory neurons yet are immunoreactive to a neuron-specific probe for neurofilament protein. These less differentiated (type-L neurons) could not be labeled retrogradely with horseradish peroxidase from the periphery or dorsal root. Despite their apparent immaturity, type-L neurons appear to have extended axons both centrally and toward the periphery, because axon number in dorsal roots and peripheral nerves was similar in juvenile and adult frogs. These findings are consistent with the existence in juvenile frogs of a population of incompletely differentiated DRG neurons that lack the physiological properties and appearance typical of mature neurons.

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Citations

Jan 4, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Aliny A B Lobo LaddAntonio A Coppi
Nov 26, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Arianna ServiliLucy E J Lee
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Jul 13, 2002·The Journal of Comparative Neurology·Paul B Farel
Aug 24, 2001·The Anatomical Record·P B Farel
Apr 27, 2002·The Journal of Comparative Neurology·Lei ZhangAndrew D McClellan

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