Neuron-astrocyte signaling network in spinal cord dorsal horn mediates painful neuropathy of type 2 diabetes.

Glia
Jacqueline R DauchHsinlin T Cheng

Abstract

Activation of the neuronal-glial network in the spinal cord dorsal horn (SCDH) mediates various chronic painful conditions. We studied spinal neuronal-astrocyte signaling interactions involved in the maintenance of painful diabetic neuropathy (PDN) in type 2 diabetes. We used the db/db mouse, an animal model for PDN of type 2 diabetes, which develops mechanical allodynia from 6 to 12 wk of age. In this study, enhanced substance P expression was detected in the presynaptic sensory fibers innervating lamina I-III in the lumbar SCDH (LSCDH) of the db/db mouse at 10 wk of age. This phenomenon is associated with enhanced spinal ERK1/2 phosphorylation in projection sensory neurons and regional astrocyte activation. In addition, peak phosphorylation of the NR1 subunit of N-methyl-D-aspartate receptor (NMDAR), along with upregulation of neuronal and inducible nitric oxide synthase (nNOS and iNOS) expression were detected in diabetic mice. Expression of nNOS and iNOS was detected in both interneurons and astrocytes in lamina I-III of the LSCDH. Treatment with MK801, an NMDAR inhibitor, inhibited mechanical allodynia, ERK1/2 phosphorylation, and nNOS and iNOS upregulation in diabetic mice. MK801 also reduced astrocytosis and glial acidic...Continue Reading

References

Dec 14, 1992·Neuroscience Letters·K F KittoG L Wilcox
Sep 2, 1966·Science·K P HummelD L Coleman
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W J Dixon
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Koichi ObataKoichi Noguchi
Mar 29, 2005·Diabetes Care·Andrew J M BoultonUNKNOWN American Diabetes Association
Jun 25, 2005·The Journal of Comparative Neurology·Sarah E SlackSophie Pezet
Oct 17, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Amy M BarrettAmy S Chappell
Sep 7, 2007·Neurobiology of Disease·Kelli A SullivanEva L Feldman
Jan 20, 2009·Brain Research Reviews·Ru-Rong JiGary R Strichartz
Apr 11, 2009·International Journal of Molecular Medicine·Igor VareniukIrina G Obrosova
Aug 29, 2009·The Journal of Pain : Official Journal of the American Pain Society·Alban Latremoliere, Clifford J Woolf
Oct 10, 2009·Journal of Neuropathology and Experimental Neurology·Hsinlin T ChengEva L Feldman
Dec 17, 2009·Frontiers in Neuroscience·Marco Aurélio M FreireAntonio Pereira
May 21, 2010·Molecular Pain·Hsinlin T ChengEva L Feldman
Sep 8, 2010·Current Opinion in Neurobiology·Simon Beggs, Michael W Salter
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yong-Jing Gao, Ru-Rong Ji
Apr 16, 2011·BMC Neuroscience·Emanuela EspositoSalvatore Cuzzocrea

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Citations

Jan 16, 2014·The Journal of Endocrinology·Donato CalabreseRoberto Cosimo Melcangi
Mar 13, 2014·ILAR Journal·Phillipe D O'BrienEva L Feldman
Dec 22, 2015·The Journal of Pain : Official Journal of the American Pain Society·Ryan B GriggsBradley K Taylor
Oct 31, 2015·Brain and Behavior·Suzana Ulian BenitezAlexandre Leite Rodrigues de Oliveira
Oct 15, 2014·Journal of Cellular and Molecular Medicine·Menachem HananiShangdong Liang
Feb 5, 2013·The Journal of Pain : Official Journal of the American Pain Society·Seo-Yeon YoonPatrick M Dougherty
Jul 10, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Ghada M El-LithyMay Hamza
Jan 3, 2014·Physiological Reviews·Martin S SteinhoffNigel W Bunnett
Jan 3, 2014·Physiological Reviews·Emmanuel BourinetGerald W Zamponi
Jul 11, 2019·Neural Regeneration Research·Vuong M PhamSeiji Ito
Dec 23, 2017·Frontiers in Neuroscience·Ryan B GriggsBradley K Taylor
May 18, 2021·Neurobiology of Disease·Kazuhisa TakahashiSoroku Yagihashi

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