Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets

Neural Plasticity
Egor DzyubenkoAndreas Faissner

Abstract

Synapses are specialized structures that mediate rapid and efficient signal transmission between neurons and are surrounded by glial cells. Astrocytes develop an intimate association with synapses in the central nervous system (CNS) and contribute to the regulation of ion and neurotransmitter concentrations. Together with neurons, they shape intercellular space to provide a stable milieu for neuronal activity. Extracellular matrix (ECM) components are synthesized by both neurons and astrocytes and play an important role in the formation, maintenance, and function of synapses in the CNS. The components of the ECM have been detected near glial processes, which abut onto the CNS synaptic unit, where they are part of the specialized macromolecular assemblies, termed perineuronal nets (PNNs). PNNs have originally been discovered by Golgi and represent a molecular scaffold deposited in the interface between the astrocyte and subsets of neurons in the vicinity of the synapse. Recent reports strongly suggest that PNNs are tightly involved in the regulation of synaptic plasticity. Moreover, several studies have implicated PNNs and the neural ECM in neuropsychiatric diseases. Here, we highlight current concepts relating to neural ECM and...Continue Reading

References

Apr 1, 1990·Biochemical Society Transactions·K DoegeY Yamada
Jan 1, 1988·Annual Review of Cell Biology·E Ruoslahti
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·A AspbergE Ruoslahti
Jan 1, 1994·Brain Research. Brain Research Reviews·M R Celio, I Blümcke
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·A RiceR J DeLorenzo
Jun 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·E S WintergerstM R Celio
Apr 11, 1997·Schizophrenia Research·C L Beasley, G P Reynolds
Oct 10, 1997·Cell and Tissue Research·A Faissner
May 30, 1998·Cell·S E Craven, D S Bredt
Jan 9, 1999·Trends in Neurosciences·M R CelioL Vitellaro-Zuccarello
Apr 15, 2000·Cellular and Molecular Life Sciences : CMLS·Y Yamaguchi
Aug 10, 2000·The Journal of Clinical Investigation·B P Toole
Oct 4, 2000·Physiological Reviews·C E Bandtlow, D R Zimmermann
Feb 22, 2001·Annual Review of Physiology·A AraqueP G Haydon
Mar 14, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·A Joester, A Faissner
Mar 21, 2001·Nature Reviews. Neuroscience·P G Haydon
Aug 4, 2001·Molecular and Cellular Biology·X H ZhouR Fässler
Nov 21, 2001·Nature Reviews. Neuroscience·J R Sanes, J W Lichtman
Mar 23, 2002·Science·Eric C BeattieRobert C Malenka
Apr 12, 2002·Nature·Elizabeth J BradburyStephen B McMahon
Apr 26, 2002·Trends in Neurosciences·Craig C GarnerNoam E Ziv
Jun 8, 2002·Science·Anis ContractorStephen F Heinemann
Aug 31, 2002·Science·Thomas BiedererThomas C Südhof

❮ Previous
Next ❯

Citations

Aug 2, 2016·Alcoholism, Clinical and Experimental Research·Louise Adermark, M Scott Bowers
Aug 30, 2016·Brain Research Bulletin·Robert KrencikErik M Ullian
Nov 12, 2016·Molecular and Cellular Neurosciences·Andreas FaissnerUrsula Theocharidis
Mar 7, 2017·Scientific Reports·Jacqueline ReinhardStephanie C Joachim
May 22, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·May J ReedRobert B Vernon
Jun 13, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ariel DiazManuel Yepes
Aug 15, 2018·Omics : a Journal of Integrative Biology·Didem Dayangac-ErdenSevim Erdem-Ozdamar
Dec 19, 2018·Journal of Neuroendocrinology·Julie A ChowenMaría Soledad Fernández-Alfonso
Feb 20, 2018·Cellular & Molecular Biology Letters·Nazli F EskiciDidem Dayangac-Erden
Mar 30, 2019·Glia·Mark Charlton-PerkinsWilliam A Harris
Feb 23, 2019·Nature Reviews. Neuroscience·Dipan C PatelHarald Sontheimer
Feb 28, 2018·Scientific Data·Masood A AkramGiorgio A Ascoli
Feb 15, 2018·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kensuke Sakamoto, James J Crowley
Apr 18, 2018·Frontiers in Cellular Neuroscience·Akihito TakedaKengo Funakoshi
Apr 30, 2019·Frontiers in Cell and Developmental Biology·Richard P Tucker, Martin Degen
Dec 21, 2019·Brain Structure & Function·Andrea HunyadiÉva Rácz
Nov 8, 2017·Frontiers in Integrative Neuroscience·Jacqueline ReinhardAndreas Faissner
Jun 17, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephanie SimardNatalina Salmaso
Oct 22, 2018·Journal of Molecular Neuroscience : MN·Hadhemi KaddourOlfa Masmoudi-Kouki
Jan 9, 2019·Frontiers in Cellular Neuroscience·Marco SancandiAudrey Mercer
Apr 2, 2019·Frontiers in Cell and Developmental Biology·Ewa E Bres, Andreas Faissner
Nov 6, 2018·Neurochemical Research·Helen A RowlandKatherine A B Kellett
Jan 9, 2019·Therapeutic Advances in Neurological Disorders·Egor DzyubenkoDirk M Hermann
Oct 7, 2020·Scientific Reports·Emily WilsonKaren Newell-Litwa
Nov 21, 2020·Neurochemical Research·Stephani C WangYu-Feng Wang
Jan 25, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A Sánchez-GonzálezA Fernández-Teruel
Jan 10, 2021·Brain Research·Masahito TakiguchiKengo Funakoshi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Cell Adhesion & Migration
Hideru TogashiYoshimi Takai
Progress in Brain Research
Anne HeikkinenMichisuke Yuzaki
Frontiers in Bioscience : a Journal and Virtual Library
Dennis O CleggErin C Tolhurst
© 2022 Meta ULC. All rights reserved