Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

Neuropharmacology
Makoto Tsuda, K Inoue

Abstract

Neuropathic pain, a chronic pain condition following nerve damage and degeneration, involves aberrant excitability in the dorsal horn of the spinal cord. A growing body of evidence has shown that the aberrant excitability might not be a consequence merely of changes in neurons, but rather of multiple alterations in glial cells, such as microglia, the immune cells of the central nervous system. Extracellular nucleotides play an important role in neuron-microglia communication through purinergic P2X and P2Y receptors expressed in microglia. Importantly, inhibiting the function or expression of these microglial molecules suppresses aberrant excitability of dorsal horn neurons and neuropathic pain, suggesting a crucial role for microglial purinergic signaling in mechanisms of neuropathic pain. Here, we describe recent advances in the understanding of neuron-microglia interactions by purinergic signaling in neuropathic pain following neurodegeneration. This article is part of the Special Issue entitled 'Purines in Neurodegeneration and Neuroregeneration'.

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Citations

Dec 24, 2015·Acta Neuropathologica Communications·Laura A N PeferoenSandra Amor
Jan 19, 2016·Neuropharmacology·Peter IllesBeata Sperlagh
Jun 9, 2016·Journal of Neuroinflammation·Ya-Qun ZhouYu-Ke Tian
Nov 7, 2017·International Journal of Molecular Sciences·Norikazu KiguchiShiroh Kishioka
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Jan 21, 2017·F1000Research·Halina Machelska, Melih Ö Celik
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Sep 10, 2020·Molecular Neurobiology·Simin TangJun Zhou
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May 24, 2017·Cellular and Molecular Neurobiology·John Alimamy KabbaTao Pang
Apr 26, 2018·Frontiers in Pharmacology·Ágatha Oliveira-GiacomelliHenning Ulrich
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Feb 16, 2019·Frontiers in Neuroscience·Trevor RajchgotSébastien Talbot
Apr 9, 2017·Neuroscience Bulletin·Makoto Tsuda
Jan 11, 2020·Frontiers in Molecular Neuroscience·Samuel KakrabaRobert J Shmookler Reis
Sep 6, 2017·Neuroscience Research·Makoto Tsuda

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