Neuron-specific enolase antibodies in patients with sudden acquired retinal degeneration syndrome

Veterinary Immunology and Immunopathology
Barbara K BrausCornelia A Deeg

Abstract

Sudden acquired retinal degeneration syndrome (SARDS) is a disease characterised by sudden and bilateral vision loss of dogs. Previous studies failed to identify the underlying cause [Mattson, A., Roberts, S.M., Isherwood, J.M.E., 1992. Clinical features suggesting hyperadrenocorticism associated with sudden acquired retinal degeneration syndrome in a dog. J. Am. Anim. Hosp. Assoc. 28, 199-202; Van der Woerdt, A., Nasisse, M.P., Davidson, M.G., 1991. Sudden acquired retinal degeneration in the dog: clinical and laboratory findings in 36 cases. Prog. Vet. Comp. Ophthamol. 1, 11-18] and earlier investigations about the occurrence of anti-retinal antibodies in SARDS patients showed inconsistent results. To provide a novel approach to those findings we designed a more detailed study. Autoantibodies of SARDS patients and normal controls were tested against the purified autoantigens S-antigen and cellular retinaldehyde binding protein (CRALBP) that play a role in human autoimmune uveitis. Next we tested the autoantibody binding pattern to whole retinal lysate. No difference in the incidence of autoantibodies could be found between SARDS patients and healthy controls while testing the well-known autoantigens S-antigen and CRALBP. Pote...Continue Reading

References

Feb 22, 1992·The Veterinary Record·D O'TooleC Nunamaker
Jan 1, 1986·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C E Margo, M Lavellée
Nov 1, 1974·Clinical Immunology and Immunopathology·G WickB Albini
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·M O KurrerJ D Katz
Nov 19, 1997·The Journal of Comparative Neurology·K A RichJ C Blanks
Oct 17, 2001·The Journal of Clinical Investigation· Lernmark A
Oct 9, 2002·The Tohoku Journal of Experimental Medicine·Ikuyo MaruyamaHiroshi Ohguro
Dec 28, 2002·Springer Seminars in Immunopathology·Jochen Seissler, Werner A Scherbaum
Jun 30, 2004·Investigative Ophthalmology & Visual Science·Cornelia A DeegBernd Kaspers
May 13, 2006·Molecular & Cellular Proteomics : MCP·Cornelia A DeegMarius Ueffing
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marielle ThewissenPiet Stinissen

❮ Previous
Next ❯

Citations

Aug 29, 2009·Neurocritical Care·Dannielle ZierathKyra J Becker
Dec 15, 2010·Archives of Ophthalmology·Audrey C KoEdwin M Stone
Nov 1, 2013·Journal of the American Veterinary Medical Association·Jane A StuckeyRichard W Madsen
Apr 3, 2012·Experimental and Molecular Pathology·Kei MorohoshiSanta J Ono
Mar 22, 2012·Veterinary Ophthalmology·Johanna K ZippliesCornelia A Deeg
Mar 28, 2013·American Journal of Veterinary Research·Stephanie A PumphreyTanya Logvinenko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.