Neuron-specific enolase during the development of the organ of Corti

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
D S Whitlon, H M Sobkowicz

Abstract

NSE immunoreactivity has been studied in the organ of Corti of the developing mouse from birth to 21 days. NSE immunohistochemical stain is observed in spiral ganglion cells, in nerve fibers and in nerve endings of inner and outer hair cells, and in both populations of sensory cells. Spiral ganglion cells in lower and central parts of the ganglion stain for NSE at birth, but all nerve cells are stained by day 4. Radial and spiral fibers and the endings on inner hair cells stain at birth, but the nerve endings on outer hair cells develop NSE between days 3 and 6. The inner and outer hair cells are NSE-positive at day 2 but the NSE immunoreactivity in the outer hair cells decreases at the end of the second week until the cells become negative. The NSE stain in the neuronal pathways of the inner and outer hair cell regions increases for about 19 days, showing a predominant accumulation in neuronal endings. The data suggest that the development of NSE expression in the organ of Corti reflects the nascence and maturation of the synaptic contacts. Spiral neurons, their fibers and endings as well as inner and outer hair cells express NSE in the isolated organ of Corti in culture. Variability of stain among the different cell populatio...Continue Reading

References

Jan 1, 1976·Annals of Human Genetics·J M PearceH Harris
Sep 1, 1978·Journal of Neurochemistry·P J MarangosF K Goodwin
Oct 1, 1976·Journal of Neurochemistry·C M JacqueE Bock
Jan 1, 1976·Biochemical Society Transactions·L FletcherC B Taylor
Oct 1, 1975·Journal of Neurocytology·H M SobkowiczJ E Rose
Sep 16, 1975·Biochemical and Biophysical Research Communications·C C Rider, C B Taylor
Jan 1, 1976·Annals of Human Genetics·S H Chen, E R Giblett
Jan 1, 1986·Hearing Research·C J Dechesne, R Pujol
Dec 1, 1986·Journal of Neurocytology·H M SobkowiczC V Levenick
May 19, 1980·Brain Research·P J MarangosF K Goodwin
Dec 1, 1980·Journal of Neurocytology·O K LangleyG Gombos
Aug 1, 1953·The Journal of Comparative Neurology·G L RASMUSSEN

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Citations

Jan 1, 1992·Acta Oto-laryngologica·M Y Mu, X Pao
Nov 1, 1991·Journal of Neurocytology·D S Whitlon, H M Sobkowicz
Dec 1, 1993·Journal of Neurocytology·D S Whitlon
Jan 1, 1991·Annals of the New York Academy of Sciences·D S Whitlon, H M Sobkowicz
Jul 1, 1991·Andrologia·W SchulzeA F Holstein
Apr 2, 1999·The Journal of Comparative Neurology·D S WhitlonM Kusakabe
Dec 1, 1990·Journal of Neurocytology·D S Whitlon, U S Rutishauser

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