Neuron theory, the cornerstone of neuroscience, on the centenary of the Nobel Prize award to Santiago Ramón y Cajal

Brain Research Bulletin
Francisco López-MuñozCecilio Alamo

Abstract

Exactly 100 years ago, the Nobel Prize for Physiology and Medicine was awarded to Santiago Ramón y Cajal, "in recognition of his meritorious work on the structure of the nervous system". Cajal's great contribution to the history of science is undoubtedly the postulate of neuron theory. The present work makes a historical analysis of the circumstances in which Cajal formulated his theory, considering the authors and works that influenced his postulate, the difficulties he encountered for its dissemination, and the way it finally became established. At the time when Cajal began his neurohistological studies, in 1887, Gerlach's reticular theory (a diffuse protoplasmic network of the grey matter of the nerve centres), also defended by Golgi, prevailed among the scientific community. In the first issue of the Revista Trimestral de Histología Normal y Patológica (May, 1888), Cajal presented the definitive evidence underpinning neuron theory, thanks to staining of the axon of the small, star-shaped cells of the molecular layer of the cerebellum of birds, whose collaterals end up surrounding the Purkinje cell bodies, in the form of baskets or nests. He thus demonstrated once and for all that the relationship between nerve cells was not...Continue Reading

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Citations

Jun 9, 2009·Histochemistry and Cell Biology·Dariusz Orlowski, Carsten R Bjarkam
Apr 8, 2009·Journal of Neural Transmission·Francisco López-Muñoz, Cecilio Alamo
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Russell W TeichertBaldomero M Olivera
Jul 23, 2013·Endeavour·Ortwin Bock
Feb 15, 2011·Brain Research Bulletin·Francisco López-MuñozCecilio Alamo
Jul 29, 2010·Trends in Neurosciences·Oliver HobertNikolaos Stefanakis
Oct 2, 2007·Journal of Chemical Neuroanatomy·Lazaros C Triarhou, Manuel del Cerro
May 11, 2007·Brain Research Reviews·Juan A De Carlos, José Borrell
Apr 22, 2015·Annual Review of Neuroscience·Gideon Rothschild, Adi Mizrahi
Jun 18, 2015·Frontiers in Neuroanatomy·Jairo A Rozo, Antonio Rodríguez-Moreno
Jun 7, 2014·Frontiers in Neuroanatomy·Vanessa GilJosé A Del Río
Nov 17, 2016·História, ciências, saúde--Manguinhos·Isabel AmaralFrancisco Rômulo Monte Ferreira
Jul 16, 2010·Nature Reviews. Neuroscience·Matthew N Rasband
Nov 12, 2010·Nature·Richard M Ransohoff, Astrid E Cardona
Jun 26, 2020·Advanced Healthcare Materials·Mary KasperChristine E Schmidt
May 15, 2020·Molecular Psychiatry·Amanda J PriceDaniel R Weinberger
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May 15, 2018·Biology & Philosophy·David Parker
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Nov 17, 2020·Frontiers in Psychology·Tuomas K Pernu, Nadine Elzein

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