Neuronal activation and corticotropin-releasing hormone expression in the brain of obese (fa/fa) and lean (fa/?) Zucker rats in response to refeeding

The European Journal of Neuroscience
Elena TimofeevaD Richard

Abstract

The present study was conducted to investigate the pattern of neuronal activation and corticotropin-releasing hormone (CRH) expression in fed, food deprived and refed lean (Fa/?) and obese (fa/fa) Zucker rats. The pattern of neuronal activation was studied by measuring the expression of the immediate-early gene c-fos. Expression of c-fos and CRH mRNA was determined by in situ hybridization histochemistry. In both lean and obese rats, one hour of refeeding led to a transient increase in c-fos mRNA levels which was detected in the paraventricular hypothalamic nucleus (PVH), the dorsomedial hypothalamic nucleus, the supraoptic nucleus, the paraventricular thalamic nucleus, the central nucleus of amygdala (CeA), the lateral and medial parabrachial nuclei, the nucleus of the solitary tract, and the area postrema. In addition, refeeding led to strong activation of the arginine-vasopressin neurons located in the magnocellular part of the PVH. Following 24 h of food deprivation, CRH expression in the parvocellular division of the PVH was significantly higher in obese rats compared to lean animals. During refeeding, PVH CRH mRNA levels in obese rats decreased to reach control values. The decrease in CRH expression in obese rats was acco...Continue Reading

References

Apr 1, 1992·Endocrinology·P M PlotskyR L Hauger
Jan 1, 1991·Annual Review of Nutrition·P R JohnsonJ S Stern
Jun 1, 1989·Metabolism: Clinical and Experimental·B D WhiteJ R Porter
May 1, 1987·Molecular Endocrinology·R C ThompsonE Herbert
Mar 1, 1983·The American Journal of Clinical Nutrition·D WalksP Björntorp
Apr 14, 1995·Neuroscience Letters·N E Rowland
Jan 1, 1995·The American Journal of Physiology·K A FraserJ S Davison
Mar 23, 1994·Annals of the New York Academy of Sciences·K A Fraser, J S Davison
May 1, 1996·Nature Genetics·M S PhillipsJ F Hess
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·S C HeinrichsE B De Souza
Feb 1, 1997·Trends in Neurosciences·J P Herman, W E Cullinan
Jan 1, 1997·The American Journal of Physiology·H Plamondon, Z Merali
Oct 1, 1997·Physiology & Behavior·B M KingH M Sam
Mar 29, 2000·Progress in Brain Research·P E SawchenkoA Ericsson
Dec 18, 2001·The Journal of Comparative Neurology·E Timofeeva, D Richard

❮ Previous
Next ❯

Citations

Oct 31, 2000·Nutrition·D RichardY Deshaies
Nov 16, 2011·The Journal of Endocrinology·F Lucio-Oliveira, C R Franci
Sep 30, 2005·The European Journal of Neuroscience·Elena TimofeevaDenis Richard
Jul 22, 2010·The European Journal of Neuroscience·Elena-Dana BaraboiDenis Richard
Nov 9, 2004·Brain Research. Molecular Brain Research·Ryan J HerringaNed H Kalin
Sep 20, 2006·Progress in Neurobiology·Norman PecoraroSusan F Akana
Oct 29, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Claire-Dominique Walker
Feb 27, 2016·The Journal of Comparative Neurology·Györgyi ZséliCsaba Fekete
Sep 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Martine DuclosDenis Richard
Nov 3, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Sang Bae YooJeong Won Jahng
May 10, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catherine M KotzChuanFeng Wang
Jul 23, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·V RyuJ W Jahng
Apr 17, 2007·The Journal of Comparative Neurology·Alan G Watts, Graciela Sanchez-Watts
Jul 22, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elena-Dana BaraboiDenis Richard
Aug 31, 2017·Brain Structure & Function·Györgyi ZséliCsaba Fekete
Sep 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T RiedigerT A Lutz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.