PMID: 9181486May 1, 1997Paper

Neuronal activation of the hypothalamic magnocellular system in response to oropharyngeal stimuli in the rat

Journal of Neuroendocrinology
N NaïmiD Richard

Abstract

The present study was designed to delineate the neuronal site, the nature, and the gastrointestinal origin of the stimulation of the hypothalamic magnocellular system induced by the ingestion of sweetened condensed milk. Concomitant localization of the c-fos protein (Fos) with either arginine-vasopressin (AVP) mRNA or oxytocin (OT) mRNA in the paraventricular nucleus of the hypothalamus (PVH) and the supraoptic nucleus (SON) revealed that the hypothalamic neurons containing AVP and OT were activated following ingestion of sweetened condensed milk. Expression of c-fos mRNA was also determined in rats implanted with a gastric cannula that allowed for real, sham, and gastric feeding of sweetened condensed milk. The results provide evidence that the stimulation of the PVH and SON induced by sweetened condensed milk originate from oropharyngeal stimuli. Indeed, in real-and sham-fed rats, the postprandial levels of c-fos mRNA in the PVH and SON were significantly higher than the preprandial values, whereas there was no early postprandial rise in c-fos mRNA levels within the magnocellular division of the PVH and SON after gastric feeding. The results of this study also suggested that the stimulation of the PVH and SON induced by sweet...Continue Reading

Citations

Jun 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea GodinoLaura Vivas
Sep 30, 2005·The European Journal of Neuroscience·Elena TimofeevaDenis Richard
Dec 4, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maiko HiroiHiroshi Arima
Apr 17, 2018·Neuroendocrinology·Yuko MaejimaKenju Shimomura
Nov 16, 2011·The Journal of Endocrinology·F Lucio-Oliveira, C R Franci
Apr 30, 1999·Progress in Neurobiology·G LengJ A Russell
Sep 26, 2009·Hormones and Behavior·Ernane Torres UchoaLucila Leico K Elias

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