Neuronal Activity at Synapse Resolution: Reporters and Effectors for Synaptic Neuroscience

Frontiers in Molecular Neuroscience
F. Gobbo, Antonino Cattaneo

Abstract

The development of methods for the activity-dependent tagging of neurons enabled a new way to tackle the problem of engram identification at the cellular level, giving rise to groundbreaking findings in the field of memory studies. However, the resolution of activity-dependent tagging remains limited to the whole-cell level. Notably, events taking place at the synapse level play a critical role in the establishment of new memories, and strong experimental evidence shows that learning and synaptic plasticity are tightly linked. Here, we provide a comprehensive review of the currently available techniques that enable to identify and track the neuronal activity with synaptic spatial resolution. We also present recent technologies that allow to selectively interfere with specific subsets of synapses. Lastly, we discuss how these technologies can be applied to the study of learning and memory.

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Citations

Apr 4, 2021·Current Opinion in Neurobiology·Tomás J RyanSiddhartha Sen
Jun 11, 2021·The FEBS Journal·Mohammad Zaki Bin IbrahimSreedharan Sajikumar

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Methods Mentioned

BETA
Transgenic
FRET
GTPase

Key Resources (RRID) Mentioned

IMSR_JAX

Software Mentioned

Syntagma
Chlomeleon
iGABASnFR
SA
Ch
mGRASP
Chlophensor
SYNPLA

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