Neuronal activity of the zona incerta in Parkinson's disease patients

Movement Disorders : Official Journal of the Movement Disorder Society
Marcelo MerelloDaniel Cerquetti

Abstract

The objective of this study was to describe the firing characteristics of the zona incerta (ZI) in Parkinson's disease patients. The ZI constitutes a band of gray matter lying dorsal to the subthalamic nucleus, whose firing properties have not been well defined in humans yet. ZI proved to become hyperactive in 6-OHDA-lesioned rats as compared to normal rats, and regarding these noticeable changes in the discharge patterns it was suggested that ZI could be a putative target for the surgical treatment of Parkinson's disease. Twelve patients who underwent microrecording-guided subthalamic surgery consented to the study. Neurons from different tracts were classified as belonging to the ZI according to their firing features, background extracellular activity, anatomical mapping of trajectories, and atlas confirmation. Fifty-nine neurons were classified as belonging to ZI. The mean firing rate proved to be 29.5 Hz, with a broad dispersion band, even covering subthalamic nucleus (STN) frequency ranges. Pattern analysis showed heterogeneous neuronal signals ranging from tonic to burst and paused neurons. A decrease in extracellular background activity in the defined ZI was also observed. Five of the recorded neurons showed rhythmical s...Continue Reading

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Citations

Apr 1, 2007·Journal of Biological Physics·Svetlana PostnovaHans A Braun
Feb 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Péter BarthóLászló Acsády
Oct 16, 2010·Acta neurochirurgica·Lo J BourP Richard Schuurman
Dec 3, 2008·Chaos·M A KomarovJ A K Suykens
May 8, 2009·The European Journal of Neuroscience·J CosteJ J Lemaire
Jul 7, 2020·Operative Neurosurgery·Maria Guadalupe García-GomarFrancisco Velasco-Campos
Apr 15, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Francisco VelascoAna Luisa Velasco
Dec 17, 2009·Neuroscience and Behavioral Physiology·A I Gorbachevskaya
Aug 4, 2019·Journal of Neurology·Krystyna Ossowska
Apr 28, 2021·Scientific Reports·Charles W LuParag G Patil
Jan 18, 2019·Stereotactic and Functional Neurosurgery·Drew S KernAlfonso Fasano

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