Neuronal activity pattern defects in the striatum in awake mouse model of Parkinson's disease

Behavioural Brain Research
Hui ChenQunyuan Xu

Abstract

Previous studies showed the loss of dopaminergic neurons directly leads to both changes in firing rate and neuronal synchrony in the striatum by pharmacogenetic approach, but physiological observation of striatal neurons in awake animal is rare up to now due to the limitation of recording methods. We use multichannel in vivo recording system, to record the activity pattern of both medium spiny projecting neurons (MSNs) and fast spiking interneurons (FSIs) in awake mouse model of Parkinson's disease (PD), created by injection of 6-hydroxyl-dopamine (6-OHDA) into dorsolateral striatum bilaterally and unilaterally. The abnormal discharge of neurons, including oscillations, burst activity and firing rate were systematically observed, and we used these index together to comprehensively analyse the functional change of striatal neurons in PD mouse model. We found that PD mouse model exhibited elevated synchronized oscillatory activity in β frequency band and decreased firing rate of FSIs during movement. The firing rate and burst activity of MSNs clearly reduced during movement after bilateral dopamine depletion. The present study has novelly shown the firing pattern changes of the MSNs and FSIs in DL striatum in awake PD mouse model...Continue Reading

Citations

May 13, 2020·The European Journal of Neuroscience·Ivan Castela, Ledia F Hernandez
Apr 3, 2019·Journal of Neural Transmission·Shenyu ZhaiD James Surmeier
Jan 11, 2020·Neurobiology of Disease·Magdalena K BaaskeChristian K E Moll
Mar 22, 2019·Neuron·Matthew M McGregor, Alexandra B Nelson

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