PMID: 8594212Oct 1, 1995Paper

Neuronal apoptosis: current understanding of molecular mechanisms and potential role in ischemic brain injury

Journal of Neurotrauma
E M JohnsonC Y Hsu

Abstract

Apoptosis is a rediscovered mechanism of cell death crucial in normal development. Recent exploration of the genetic mechanisms of apoptosis has broadened our insight into the regulation of cell death in development as well as disease states. We present an overview on current understanding of the genetic molecular events in apoptosis in all, or most cell types, with emphasis on events observed in a well-characterized model of neuronal death in vitro. The second part of this article reviews recent studies in in vivo stroke models on the mechanism of cell death relevant to apoptosis after cerebral ischemia. Further delineation of the mechanisms of cell death, especially those that trigger apoptosis, is likely to redirect our approaches in the development of new therapeutic interventions for ischemic stroke.

References

Dec 11, 1992·Toxicology Letters·S OrreniusP Nicotera
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F A WelshV A Harris
Jun 1, 1992·Stroke; a Journal of Cerebral Circulation·D XueA M Buchan
Aug 30, 1991·Biochemical and Biophysical Research Communications·S KureK Narisawa
Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D J CombsM S Kindy
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KinouchiP H Chan
Dec 31, 1991·Biochemical and Biophysical Research Communications·B DipasqualeR J Youle
Apr 1, 1991·Stroke; a Journal of Cerebral Circulation·T N LinG Y Sun
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·B KaplanW Pulsinelli
Nov 1, 1991·Experimental Cell Research·D M OjciusJ D Young
Jan 1, 1990·Annual Review of Neuroscience·D W Choi, S M Rothman
May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T S Nowak
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F R SharpK Hisanaga
Jan 1, 1990·Stroke; a Journal of Cerebral Circulation·C GustafssonJ Svensson
Oct 1, 1989·Annals of Neurology·W D Snider, E M Johnson
Jun 1, 1989·Neuron·Y A Barde
Jan 1, 1989·Annals of the New York Academy of Sciences·C Y HsuB A Freeman
Jun 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M JacewiczW A Pulsinelli
Jul 1, 1974·Journal of Neuropathology and Experimental Neurology·J H Garcia, Y Kamijyo
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer

❮ Previous
Next ❯

Citations

Feb 11, 1999·Journal of Neuroscience Research·G M Smith, M I Romero
Jul 15, 2000·Archives of Pharmacal Research·S Y ParkJ Y Kong
Jul 6, 2013·Anatomical Science International·M JahanshahiF Babakordi
Jun 2, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Ling WeiShan Ping Yu
Dec 5, 1997·The Annals of Thoracic Surgery·G K KanellopoulosN T Kouchoukos
Jul 23, 1999·Survey of Ophthalmology·N N OsborneM S Nash
Jul 20, 2002·Brain Research. Developmental Brain Research·William M HumphreyJohn G Csernansky
Feb 12, 1999·Brain Research. Developmental Brain Research·E M MontgomeryJ G Csernansky
May 16, 1998·Brain Research. Molecular Brain Research·K KanazawaA Wanaka
May 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·S P MahadikH Lal
Sep 10, 2003·Progress in Neurobiology·Shan Ping Yu
Jul 11, 1997·Neuroscience Letters·B A CitronB W Festoff
Mar 29, 2001·Brain Research. Brain Research Protocols·W M HumphreyJ G Csernansky
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·H HaraM A Moskowitz
Apr 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H HaraM A Moskowitz
Jun 17, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y TuJ P MacManus
Jan 14, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C A DaviesN J Rothwell
Feb 25, 1998·Spine·I V SmirnovaB W Festoff
Aug 1, 1997·Neuropathology and Applied Neurobiology·R J Scott, L Hegyi
Oct 3, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·K MoriE W Dickson
Jun 22, 2002·Annals of the New York Academy of Sciences·Philip K LiuAlex Valadka
Jan 15, 1997·The Journal of Clinical Investigation·A J GunnP D Gluckman
Aug 18, 2004·Journal of Neurosurgery·Narendra NathooRunjan Chetty
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Jian-Feng ChenTian-Si Tang
Sep 5, 2014·Cellular and Molecular Neurobiology·Negar Shafaei-BajestaniZahra Tayarani-Najaran
Jan 11, 2014·Journal of Exercise Rehabilitation·Jin-Hwan YoonSoon Gi Baek
Oct 9, 2002·Current Medical Research and Opinion·Paul T Akins, Richard P Atkinson
Jun 18, 2010·Neurobiology of Disease·Jian-Hua ZhangMichael H Chase
Apr 26, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhao Zhong ChongKenneth Maiese

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.