Neuronal Avalanches to Study the Coordination of Large-Scale Brain Activity: Application to Rett Syndrome

Frontiers in Psychology
Rosaria RuccoPierpaolo Sorrentino

Abstract

Many complex systems, such as the brain, display large-scale coordinated interactions that create ordered patterns. Classically, such patterns have been studied using the framework of criticality, i.e., at a transition point between two qualitatively distinct patterns. This kind of system is generally characterized by a scale-invariant organization, in space and time, optimally described by a power-law distribution whose slope is quantified by an exponent α. The dynamics of these systems is characterized by alternating periods of activations, called avalanches, with quiescent periods. To maximize its efficiency, the system must find a trade-off between its stability and ease of propagation of activation, which is achieved by a branching process. It is quantified by a branching parameter σ defined as the average ratio between the number of activations in consecutive time bins. The brain is itself a complex system and its activity can be described as a series of neuronal avalanches. It is known that critical aspects of brain dynamics are modeled with a branching parameter σ = , and the neuronal avalanches distribution fits well with a power law distribution exponent α = -3/2. The aim of our work was to study a self-organized crit...Continue Reading

References

Mar 1, 1995·Journal of Neuropathology and Experimental Neurology·D ArmstrongR Trivedi
Sep 1, 1997·IEEE Transactions on Bio-medical Engineering·B D Van VeenA Suzuki
Sep 22, 1998·Science·B D MalamudD L Turcotte
Jan 1, 1996·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·M PaczuskiP Bak
Jul 27, 1987·Physical Review Letters·P BakK Wiesenfeld
Nov 27, 1995·Physical Review Letters·S ZapperiH E Stanley
Oct 6, 2000·Physical Review Letters· de Carvalho JX, C P Prado
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
May 29, 2004·Neural Computation·Nils Bertschinger, Thomas Natschläger
Dec 15, 2010·Annals of Neurology·Jeffrey L NeulUNKNOWN RettSearch Consortium
Jan 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Woodrow L ShewDietmar Plenz
Jan 22, 2011·Computational Intelligence and Neuroscience·Robert OostenveldJan-Mathijs Schoffelen
Jan 14, 2012·PLoS Computational Biology·Christian MeiselThilo Gross
Oct 11, 2012·NeuroImage·Joachim GrossJan-Mathijs Schoffelen
Apr 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Oren ShrikiDietmar Plenz
Nov 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christian MeiselPeter Achermann
Jun 11, 2015·Human Molecular Genetics·Amy E Pohodich, Huda Y Zoghbi
Apr 21, 2016·Scientific Reports·F LombardiL de Arcangelis
Jul 8, 2016·Cerebral Cortex·Erik D FagerholmDavid J Sharp
May 5, 2017·Nature Communications·A Levina, V Priesemann
Dec 24, 2018·Frontiers in Aging Neuroscience·Francesca JaciniGiuseppe Sorrentino
Feb 10, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rosaria RuccoPierpaolo Sorrentino
Jul 17, 2019·Computer Methods in Biomechanics and Biomedical Engineering·Antonietta SorrisoFabio Baselice

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