Neuronal bases of directional expectation and anticipatory pursuit.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
C de HemptinneMarcus Missal

Abstract

Expectation of upcoming events is an essential cognitive function on which anticipatory actions are based. The neuronal basis of this prospective representation is poorly understood. We trained rhesus monkeys in a smooth-pursuit task in which the direction of upcoming target motion was indicated using a color cue. Under these conditions, directional expectation frequently evoked anticipatory smooth movements. We found that the activity of a population of neurons in the supplementary eye fields encoded the expected future direction of the target. Neuronal activity increased after presentation of the cue, indicating future target motion in the preferred direction. Neuronal activity either remained unaltered or was reduced if the antipreferred direction was cued. In addition, approximately 30% of these neurons were more active during trials with anticipatory pursuit in the preferred direction than during trials when monkeys did not anticipate target motion onset. This subset of recorded neurons encoded the direction of the subsequent anticipatory pursuit. We hypothesize that the neural representation of directional expectation could be conceptualized as a competitive interaction between pools of neurons representing likely future ...Continue Reading

Citations

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Sep 9, 2011·Journal of Neurophysiology·S J HeinenS N Yang
Nov 3, 2011·PloS One·Laetitia CirilliMarcus Missal
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Jul 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miriam SperingDaniel C Javitt
Oct 22, 2010·Experimental Brain Research·C de HemptinneM Missal
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