Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Kate L BlethynVincenzo Crunelli

Abstract

During deep sleep and anesthesia, the EEG of humans and animals exhibits a distinctive slow (<1 Hz) rhythm. In inhibitory neurons of the nucleus reticularis thalami (NRT), this rhythm is reflected as a slow (<1 Hz) oscillation of the membrane potential comprising stereotypical, recurring "up" and "down" states. Here we show that reducing the leak current through the activation of group I metabotropic glutamate receptors (mGluRs) with either trans-ACPD [(+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid] (50-100 microM) or DHPG [(S)-3,5-dihydroxyphenylglycine] (100 microM) instates an intrinsic slow oscillation in NRT neurons in vitro that is qualitatively equivalent to that observed in vivo. A slow oscillation could also be evoked by synaptically activating mGluRs on NRT neurons via the tetanic stimulation of corticothalamic fibers. Through a combination of experiments and computational modeling we show that the up state of the slow oscillation is predominantly generated by the "window" component of the T-type Ca2+ current, with an additional supportive role for a Ca2+-activated nonselective cation current. The slow oscillation is also fundamentally reliant on an Ih current and is extensively shaped by both Ca2+- and Na+-act...Continue Reading

Citations

Sep 12, 2008·Pflügers Archiv : European journal of physiology·Lucius CueniAnita Lüthi
Aug 24, 2011·Pflügers Archiv : European journal of physiology·Nathalie LerescheVincenzo Crunelli
Sep 6, 2011·Pflügers Archiv : European journal of physiology·Vincenzo CrunelliStuart W Hughes
Jan 26, 2012·Neuromolecular Medicine·Thien Thanh Dang-Vu
Dec 8, 2009·Nature Neuroscience·Vincenzo Crunelli, Stuart W Hughes
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Thien Thanh Dang-VuPierre Maquet
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Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Angela KimHee-Sup Shin
Sep 7, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Vincenzo CrunelliTibor I Tóth
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