Neuronal brain injury after cerebral ischemic stroke is ameliorated after subsequent administration of (R)-ketamine, but not (S)-ketamine

Pharmacology, Biochemistry, and Behavior
Zhongwei XiongKenji Hashimoto

Abstract

Although stroke is the most common acute cerebrovascular disease, there are no currently effective therapeutic drugs for ischemic stroke. (R,S)-ketamine has been shown to protect against brain injury in rodents after middle cerebral artery occlusion (MCAO). Interestingly, we reported that (R)-ketamine has greater beneficial effects than (S)-ketamine in animal models of depression and Parkinson's disease. This study was undertaken whether two enantiomers of ketamine show neuroprotective effects in MCAO model. MCAO-induced brain injury and behavioral abnormalities in mice was attenuated by subsequent administration of (R)-ketamine (10 mg/kg, twice, 1 and 24 h after MCAO), but not (S)-ketamine (10 mg/kg, twice, 1 and 24 h after MCAO). Furthermore, the treatment with (R)-ketamine (10 mg/kg, twice, 30 min before and 24 h after MCAO) significantly protected against brain injury and behavioral abnormalities in mice after MCAO. These findings suggest that (R)-ketamine can protect against neuronal injury and behavioral abnormalities in mice after MCAO. Therefore, it is likely that (R)-ketamine could represent a therapeutic drug for ischemic stroke.

References

Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A SwansonF R Sharp
Aug 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·D T WadeR A Hewer
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·M AströmK Asplund
Feb 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F X VollenweiderJ Angst
Aug 6, 2000·Stroke; a Journal of Cerebral Circulation·K HattoriA C DeVries
Jul 23, 2005·Anesthesia and Analgesia·Sabine Himmelseher, Marcel E Durieux
Aug 10, 2010·Anesthesiology·Edward F Domino
Dec 10, 2013·Pharmacology, Biochemistry, and Behavior·Ji-Chun ZhangKenji Hashimoto
Dec 11, 2014·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Leyla GulerMurat Unlu
Jul 15, 2015·Oxidative Medicine and Cellular Longevity·Suryamin LimanMichael Irwin
May 6, 2016·Critical Care : the Official Journal of the Critical Care Forum·Mauro OddoGiuseppe Citerio
Jun 5, 2016·Brain Research Bulletin·Yu LiuWenhua Zhou
Sep 21, 2016·Expert Opinion on Therapeutic Targets·Kenji Hashimoto
Jan 25, 2017·The Journal of Pharmacology and Experimental Therapeutics·Kenichi FukumotoShigeyuki Chaki
Mar 2, 2017·JAMA Psychiatry·Gerard SanacoraUNKNOWN American Psychiatric Association (APA) Council of Research Task Force on Novel Biomarkers and Treatments
Aug 2, 2017·The Lancet. Psychiatry·Brooke ShortColleen K Loo
Nov 21, 2017·The International Journal of Neuropsychopharmacology·Kai ZhangKenji Hashimoto
Nov 21, 2017·The International Journal of Neuropsychopharmacology·Yukihiko Shirayama, Kenji Hashimoto
Jun 28, 2018·Pharmacological Reviews·Panos ZanosTodd D Gould
Dec 5, 2018·Expert Review of Neurotherapeutics·Kai Zhang, Kenji Hashimoto
Jan 11, 2020·EClinicalMedicine·Kenji Hashimoto
Feb 9, 2020·Pharmacology, Biochemistry, and Behavior·Yan WeiKenji Hashimoto
Feb 23, 2020·European Archives of Psychiatry and Clinical Neuroscience·Gustavo C LealLucas C Quarantini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.