Neuronal calcium wave propagation varies with changes in endoplasmic reticulum parameters: a computer model

Neural Computation
Samuel A NeymotinWilliam W Lytton

Abstract

Calcium (Ca²⁺) waves provide a complement to neuronal electrical signaling, forming a key part of a neuron's second messenger system. We developed a reaction-diffusion model of an apical dendrite with diffusible inositol triphosphate (IP₃), diffusible Ca²⁺, IP₃ receptors (IP₃Rs), endoplasmic reticulum (ER) Ca²⁺ leak, and ER pump (SERCA) on ER. Ca²⁺ is released from ER stores via IP₃Rs upon binding of IP₃ and Ca²⁺. This results in Ca²⁺-induced-Ca²⁺-release (CICR) and increases Ca²⁺ spread. At least two modes of Ca²⁺ wave spread have been suggested: a continuous mode based on presumed relative homogeneity of ER within the cell and a pseudo-saltatory model where Ca²⁺ regeneration occurs at discrete points with diffusion between them. We compared the effects of three patterns of hypothesized IP₃R distribution: (1) continuous homogeneous ER, (2) hotspots with increased IP₃R density (IP₃R hotspots), and (3) areas of increased ER density (ER stacks). All three modes produced Ca²⁺ waves with velocities similar to those measured in vitro (approximately 50-90 μm /sec). Continuous ER showed high sensitivity to IP₃R density increases, with time to onset reduced and speed increased. Increases in SERCA density resulted in opposite effects. T...Continue Reading

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G W De Young, J Keizer
Oct 1, 1992·Journal of Neurophysiology·D A McCormick, J R Huguenard
Apr 1, 1985·The Journal of Cell Biology·W B Busa, R Nuccitelli
Jan 1, 1980·CRC Critical Reviews in Biochemistry·R H Kretsinger
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·M TerasakiT S Reese
Nov 1, 1996·Journal of the American Medical Informatics Association : JAMIA·B E PetersonG M Shepherd
Aug 11, 1998·Neuron·M J Berridge
Sep 24, 1998·Biophysical Journal·R A Fontanilla, R Nuccitelli
Oct 3, 1999·Physiological Reviews·P Lipton
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·A E WestM E Greenberg
Nov 5, 2002·Nature Reviews. Neuroscience·Frank M LaFerla
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Sten OrreniusPierluigi Nicotera
May 29, 2004·FEBS Letters·Thomas E GunterJason D Salter
Jun 26, 2004·Journal of Computational Neuroscience·Michael L HinesGordon M Shepherd
Mar 5, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Grace E Stutzmann
Jul 29, 2005·Cellular and Molecular Neurobiology·William N RossNechama Lasser-Ross
Nov 17, 2005·Journal of the National Cancer Institute. Monographs·Cynthia L HartsfieldDiana S M Buist
Aug 29, 2006·Neuroscience·M IftincaG W Zamponi
Aug 11, 2007·The Journal of Physiology·Min Hong, William N Ross
Mar 6, 2008·Journal of Computational Neuroscience·Bradford E Peercy
Mar 29, 2008·PLoS Computational Biology·Isaac ShemerSten Grillner
May 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Milena WinogradMaria V Sanchez-Vives
Jun 3, 2008·PLoS Computational Biology·Erik De Schutter
Aug 1, 2008·Neuron·Kim N Green, Frank M LaFerla
Mar 20, 2010·Nature Reviews. Neuroscience·Jeanette Hellgren Kotaleski, Kim T Blackwell
Oct 29, 2010·Cold Spring Harbor Perspectives in Biology·Colin W Taylor, Stephen C Tovey
Jun 8, 2013·Journal of Neuroscience Methods·K T Blackwell
Oct 5, 2013·Journal of Neuroscience Methods·Robert A McDougalWilliam W Lytton
Dec 4, 2013·Frontiers in Neuroinformatics·Robert A McDougalWilliam W Lytton
Feb 25, 2014·Progress in Molecular Biology and Translational Science·Zachary H TaxinWilliam W Lytton
Apr 26, 2014·Frontiers in Computational Neuroscience·Mark S RowanWilliam W Lytton
Jan 1, 2014·Journal of Computational Surgery·William W LyttonCliff C Kerr

❮ Previous
Next ❯

Citations

Jul 6, 2016·Frontiers in Pharmacology·Samuel A NeymotinWilliam W Lytton
Oct 31, 2016·Neuroscience·Adel AlturkiSatish S Nair
Sep 16, 2016·Journal of Computational Neuroscience·Robert A McDougalMichael L Hines
Apr 6, 2016·IEEE Transactions on Bio-medical Engineering·Robert A McDougalWilliam W Lytton
Oct 21, 2016·Journal of Neurophysiology·Samuel A NeymotinWilliam W Lytton
Nov 2, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sergio L AnguloHerman Moreno
Oct 30, 2019·Cells·Nicholas E Karagas, Kartik Venkatachalam
May 14, 2020·International Journal of Molecular Sciences·Bela PappHoma Adle-Biassette
Sep 26, 2017·ACM Transactions on Modeling and Computer Simulation : a Publication of the Association for Computing Machinery·Zhongwei LinMichael L Hines
Dec 12, 2017·Journal of Simulation : JOS·Zhongwei LinMichael L Hines
Apr 27, 2018·Bulletin of Mathematical Biology·Serena Dipierro, Enrico Valdinoci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.