PMID: 9445003Jan 28, 1998Paper

Neuronal cell surface molecules mediate specific binding to rabies virus glycoprotein expressed by a recombinant baculovirus on the surfaces of lepidopteran cells

Journal of Virology
C TuffereauM C Fishman

Abstract

The existence of specific rabies virus (RV) glycoprotein (G) binding sites on the surfaces of neuroblastoma cells is demonstrated. Spodoptera frugiperda (Sf21) cells expressing G of the RV strain CVS (Gcvs-Sf21 cells) bind specifically to neuroblastoma cells of different species but not to any other cell type (fibroblast, myoblast, epithelial, or glioma). Attachment to mouse neuroblastoma NG108-15 cells is abolished by previous treatment of Gcvs-Sf2 cells with anti-G antibody. Substitutions for lysine at position 330 and for arginine at position 333 in RV G greatly reduce interaction between Gcvs-Sf21 cells and NG108-15 cells. These data are consistent with in vivo results: an avirulent RV mutant bearing the same double mutation is not able to infect sensory neurons or motoneurons (P. Coulon, J.-P. Ternaux, A. Flamand, and C. Tuffereau, J. Virol. 72:273-278, 1998) after intramuscular inoculation into a mouse. Furthermore, infection of NG108-15 cells by RV but not by vesicular stomatitis virus leads to a reduction of the number of binding sites at the neuronal-cell surface. Our data strongly suggest that these specific attachment sites on neuroblastoma cells represent a neuronal receptor(s) used by RV to infect certain types of ...Continue Reading

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Citations

May 20, 1999·Molecular Membrane Biology·Y GaudinR Ruigrok
Oct 12, 2000·Journal of Virology·Y JacobN Tordo
Aug 31, 1999·The Journal of General Virology·B KissiH Bourhy
Nov 1, 2016·Archives of Virology·Renato Mancini AstrayCarlos Augusto Pereira
Jul 7, 2020·Biotechnology Progress·Livia PilattiElisabeth de Fátima Pires Augusto
Nov 21, 2001·The Journal of General Virology·C TuffereauP Perrin
Nov 26, 1999·The Journal of General Virology·H BourhyE C Holmes
Aug 16, 2005·The Journal of General Virology·Ludmilla SissoëffChristine Tuffereau
Oct 12, 2010·Journal of Drug Targeting·Lixin XiangChanghua Hu
Apr 5, 2005·Journal of Neurovirology·Monique Lafon
Dec 16, 1998·Journal of Virology·C JalletP Perrin
Aug 10, 1999·Journal of Virology·M BearzottiM Bremont
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ziyao KangKeliang Liu
Feb 6, 2017·Antiviral Research·Junhua HuangZhen F Fu
Mar 7, 2002·Virology·Edward C HolmesHervé Bourhy

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