Neuronal cell transplantation for Parkinson's and Huntington's diseases

British Medical Bulletin
Stephen B DunnettE M Torres

Abstract

The brain constitutes a privileged transplantation site. Under appropriate conditions neuronal tissues can survive transplantation into the damaged brain, integrate with the host, and alleviate functional impairments associated with neurological disease. The experimental techniques have been developed to the point of clinical application with demonstrable benefit in Parkinson's disease, and similar applications in Huntington's disease appear to be imminent. Nevertheless, present techniques require use of embryonic/fetal tissues which will limit the availability of donors for the foreseeable future. There is an active search for alternative sources of tissue that are equally effective but more readily available, including engineered cells, expanded stem/precursor cells, and xenografts.

Citations

Nov 26, 2003·Experimental Neurology·Máté D Döbrössy, Stephen B Dunnett
Sep 11, 2003·Journal of Neuroimmunology·Changying LingZsuzsa Fabry
Sep 2, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Peter E Batchelor, David W Howells
Jun 16, 2011·Stem Cells and Development·Laurent Lecanu
Feb 24, 2001·Neurological Research·K BaramiW D Lyman
Oct 28, 2005·Brain : a Journal of Neurology·Saga JohanssonChristian Spenger
Dec 12, 2018·Frontiers in Cell and Developmental Biology·Caghan Kizil, Prabesh Bhattarai
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May 27, 2008·Brain Research Bulletin·Robert H AndresHans Rudolf Widmer

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