Abstract
The brain constitutes a privileged transplantation site. Under appropriate conditions neuronal tissues can survive transplantation into the damaged brain, integrate with the host, and alleviate functional impairments associated with neurological disease. The experimental techniques have been developed to the point of clinical application with demonstrable benefit in Parkinson's disease, and similar applications in Huntington's disease appear to be imminent. Nevertheless, present techniques require use of embryonic/fetal tissues which will limit the availability of donors for the foreseeable future. There is an active search for alternative sources of tissue that are equally effective but more readily available, including engineered cells, expanded stem/precursor cells, and xenografts.
Citations
Feb 5, 2000·Journal of Neuroscience Research·N CortezJ Segovia
Sep 25, 2002·Journal of Neuroscience Research·Vandana Zaman, Ashok K Shetty
Nov 26, 2003·Experimental Neurology·Máté D Döbrössy, Stephen B Dunnett
Aug 26, 1999·Life Sciences·F TrejoJ Segovia
Sep 11, 2003·Journal of Neuroimmunology·Changying LingZsuzsa Fabry
Mar 21, 2001·Archives of Medical Research·V Anaya-MartínezF García-Hernández
Jun 16, 2001·Neurochemistry International·C D EarlR Morgenstern
Sep 2, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Peter E Batchelor, David W Howells
Feb 24, 2005·Stem Cells and Development·Mary B NewmanPaul R Sanberg
Jun 16, 2011·Stem Cells and Development·Laurent Lecanu
Oct 12, 2012·PloS One·Rosemary A FrickerMonte A Gates
Feb 24, 2001·Neurological Research·K BaramiW D Lyman
Nov 8, 2014·Neurological Research·Mahmoud HosseiniMohammad Reza Hashemzadeh
Jan 12, 2000·Experimental Neurology·R L Branton, D J Clarke
Mar 15, 2006·Experimental Neurology·Annette Møller Dall, Jens Zimmer
Dec 5, 2003·Cell Transplantation·C WattsJ D Pickard
Jul 3, 2007·Hippocampus·Ashok K Shetty, Bharathi Hattiangady
Oct 28, 2005·Brain : a Journal of Neurology·Saga JohanssonChristian Spenger
Dec 12, 2018·Frontiers in Cell and Developmental Biology·Caghan Kizil, Prabesh Bhattarai
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H WenkelM J Young
May 27, 2008·Brain Research Bulletin·Robert H AndresHans Rudolf Widmer