Neuronal changes after chronic high blood pressure in animal models and its implication for vascular dementia

Synapse
Gonzalo FloresMa de Jesús Gomez-Villalobos

Abstract

Vascular dementia is a devastating disorder not only for the patient, but also for the family because this neurocognitive disorder breaks the patient's independence, and leads to family care of the patient with a high cost for the family. This complex disorder alters memory, learning, judgment, emotional control and social behavior and affects 4% of the elderly world population. The high blood pressure or arterial hypertension is a major risk factor for cerebrovascular disease, which in most cases leads to vascular dementia. Interestingly, this neurocognitive disorder starts after long lasting hypertension, which is associated with reduced cerebral blood flow or hypoperfusion, and complete or incomplete ischemia with cortical thickness. Animal models have been generated to elucidate the pathophysiology of this disorder. It is known that dendritic complexity determines the receptive synaptic contacts, and the loss of dendritic spine and arbor stability are strongly associated with dementia in humans. This review evaluates relevant data of human and animal models that have investigated the link between long-lasting arterial hypertension and neural morphological changes in the context of vascular dementia. We examined the effect o...Continue Reading

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Citations

Sep 16, 2016·Neural Regeneration Research·Gonzalo FloresAlfonso Diaz
Feb 22, 2017·Journal of Chemical Neuroanatomy·Samuel TreviñoAlfonso Díaz
May 2, 2018·Journal of Personalized Medicine·Jacqueline R HalladayJonathan C Schisler
Nov 21, 2018·Synapse·Alejandra Aketzalli Flores-GómezGonzalo Flores
Apr 9, 2019·Synapse·Yaredit Margarita Flores-VivaldoGonzalo Flores
Nov 19, 2019·Neural Plasticity·Benjamin Maïer, Nathalie Kubis
Sep 17, 2020·International Journal of Clinical Practice·Gonzalo Flores
Oct 14, 2019·Life Sciences·Yury Yu BorshchevMichael M Galagudza
Dec 1, 2020·Frontiers in Aging Neuroscience·Ying ZhouMian Peng

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