Neuronal coupling by endogenous electric fields: cable theory and applications to coincidence detector neurons in the auditory brain stem

Journal of Neurophysiology
Joshua H Goldwyn, John Rinzel

Abstract

The ongoing activity of neurons generates a spatially and time-varying field of extracellular voltage (Ve). This Ve field reflects population-level neural activity, but does it modulate neural dynamics and the function of neural circuits? We provide a cable theory framework to study how a bundle of model neurons generates Ve and how this Ve feeds back and influences membrane potential (Vm). We find that these "ephaptic interactions" are small but not negligible. The model neural population can generate Ve with millivolt-scale amplitude, and this Ve perturbs the Vm of "nearby" cables and effectively increases their electrotonic length. After using passive cable theory to systematically study ephaptic coupling, we explore a test case: the medial superior olive (MSO) in the auditory brain stem. The MSO is a possible locus of ephaptic interactions: sounds evoke large (millivolt scale)Vein vivo in this nucleus. The Ve response is thought to be generated by MSO neurons that perform a known neuronal computation with submillisecond temporal precision (coincidence detection to encode sound source location). Using a biophysically based model of MSO neurons, we find millivolt-scale ephaptic interactions consistent with the passive cable t...Continue Reading

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Citations

Sep 6, 2017·ELife·Thomas McColganRichard Kempter
Feb 1, 2019·Journal of Neural Engineering·Alessio Paolo BuccinoAslak Tveito
Oct 18, 2019·PLoS Computational Biology·Helmut Schmidt, Thomas R Knösche
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Sep 15, 2018·Communicative & Integrative Biology·František Baluška, William B Miller
Jun 20, 2019·Frontiers in Neuroinformatics·Aaron R Shifman, John E Lewis
Feb 9, 2021·PLoS Computational Biology·Helmut SchmidtThomas R Knösche

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