PMID: 2096317Dec 1, 1990Paper

Neuronal cytoskeletal lesions induced in the CNS by intraventricular and intravenous aluminium maltol in rabbits

Neuropathology and Applied Neurobiology
C D KatsetosM R Wills

Abstract

The antigenicity of neuronal cytoskeletal lesions was studied immunohistochemically in adult New Zealand white rabbits after intraventricular (subacute) and intravenous (chronic) administration of a water-soluble aluminium compound, aluminium (Al) maltol. After short-term intraventricular administration, rabbits developed widespread neurofibrillary degeneration (NFD) involving pyramidal neurons of the isocortex and allocortex, projection neurons of the diencephalon, and nerve cells of the brain stem and spinal cord. There was a predilection for motor neuron involvement and for the infratentorial portions of the neuraxis. Perikarya and proximal neurites were especially affected. Bundles of 10 nm filaments were frequently present. Three of the animals treated intravenously for 12 weeks or longer displayed NFD in the oculomotor complex and in the pyramidal neurons of the occipital isocortex. Following either mode of administration, the affected neurons exhibited immunostaining with a panel of monoclonal antibodies (MAbs) against phosphorylated (SMI-31), non-phosphorylated/phosphatase-sensitive (SMI-32), and dephosphorylation-independent (SMI-33) epitopes of high and middle molecular weight neurofilament (NF) protein subunits. They...Continue Reading

References

Jan 22, 1976·The New England Journal of Medicine·A C AlfreyW D Kaehny
Jan 1, 1986·Acta Neuropathologica·A Bizzi, P Gambetti
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V M LeeR A Lazzarini
Jul 1, 1988·Journal of Neuropathology and Experimental Neurology·L C CorkD L Price
Nov 1, 1988·Journal of Neuropathology and Experimental Neurology·V ManettoP Gambetti
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V M LeeJ Q Trojanowski
Feb 1, 1989·The Journal of Cell Biology·P J Hollenbeck
Jan 1, 1989·Acta Neuropathologica·H BraakP Kalus
Mar 14, 1985·The New England Journal of Medicine·C G Rasool, D J Selkoe
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·M R Wills, J Savory
Jan 1, 1989·Acta Neuropathologica·R M GarrutoD C Gajdusek
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H ZhangL A Sternberger
Nov 11, 1988·Neuroscience Letters·P N LeighD M Power
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·N M Buckley
Apr 10, 1987·Science·T L MacdonaldR B Martin
Apr 29, 1988·Biochemical and Biophysical Research Communications·K B Pierson, M A Evenson
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N H SternbergerJ Ulrich
Nov 1, 1988·Journal of Neuropathology and Experimental Neurology·L C CorkD L Price
Jan 1, 1988·Journal of Neuropathology and Experimental Neurology·D G MunozD J Selkoe
Apr 1, 1988·Brain Research·N A MumaD L Price
Jan 1, 1986·Journal of Neuropathology and Experimental Neurology·L C CorkD L Price
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R D Burgoyne
Oct 20, 1967·Acta Neuropathologica·H WiśniewskiK Wiśniewska
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K S KosikD J Selkoe
Jan 1, 1984·Acta Neuropathologica·H M WisniewskiJ A Sturman
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L A Sternberger, N H Sternberger

❮ Previous
Next ❯

Citations

Jan 1, 1994·Acta Neuropathologica·J P Müller, A Bruinink
Jan 1, 1993·Molecular Neurobiology·L C Doering
Aug 1, 1994·Molecular Neurobiology·R F Itzhaki
Feb 1, 1991·Neuropathology and Applied Neurobiology·C D HewittM R Wills
Apr 1, 1997·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·O GuillardO Furon
Sep 7, 2005·Toxicology Letters·Keiko MurakamiMasataka Yoshino
Jun 1, 1992·Journal of Neurochemistry·J F LeterrierJ Ulrich
Jan 4, 2007·Chemistry : a European Journal·Anna F A PeacockPeter J Sadler
Nov 21, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Noriyuki KimuraEisaku Ohama
Mar 17, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jean-Pierre de ChadarévianChristos D Katsetos
Oct 17, 2017·Deutsches Ärzteblatt International·Katrin KlotzHans Drexler

❮ Previous
Next ❯