Neuronal damage and calcium accumulation following transient cerebral ischemia in the rat

Molecular and Chemical Neuropathology
T ArakiM Murakami

Abstract

The purpose of this study was to examine the distribution of neuronal damage following transient cerebral ischemia in the rat model of four-vessel occlusion utilizing light microscopy as well as 45Ca-autoradiography. Transient ischemia was induced for 30 min. The animals were allowed to survive for 7 d after ischemia. In the animals subjected to ischemia, the most frequently and seriously damaged areas were the paramedian region of hippocampus, the hippocampal CA1 sector, and the dorsolateral part of striatum, followed by the inferior colliculus, the substantia nigra, the frontal cortex, and the thalamus, which were moderate damaged. Furthermore, the cerebellar Purkinje neurons, the hippocampal CA4 sector, the medial geniculate body, and the hippocampal CA3 sector were slightly affected. 45Ca-autoradiographyic study also revealed calcium accumulation in the identical sites of ischemic neuronal damage, except for the frontal cortex. Regional cerebral blood flow during 10 min of ischemia was severely decreased in selectively vulnerable areas. The blood flow in the medial geniculate body, the substantia nigra, the inferior colliculus, and the cerebellum was less pronounced than that in the selectively vulnerable areas. The present...Continue Reading

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Citations

Mar 1, 1992·Pharmacology, Biochemistry, and Behavior·T ArakiY Ishida
Jun 1, 1992·Brain Research Bulletin·T ArakiK Kogure
Oct 1, 1992·Journal of Basic and Clinical Physiology and Pharmacology·D WermelskirchenT Peters
May 1, 1992·Stroke; a Journal of Cerebral Circulation·T InoueK Kogure
Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T ArakiK Kogure
Dec 29, 2020·Frontiers in Systems Neuroscience·Tanuja Bordia, Natalie M Zahr

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