Neuronal death in developmental models: possible implications in neuropathology

Brain Pathology
E M JohnsonM Deshmukh

Abstract

Extensive neuronal death occurs in the developing nervous system. Death of neurons during this process is apoptotic and appears to utilize a pathway that is conserved in various mammalian cells and organisms. Recent evidence suggests that neuronal death during trauma, stroke, or neurodegenerative diseases may also occur by a similar mechanism. This review discusses the molecular mechanism of developmental neuronal death by examining the biochemical and molecular events associated with neuronal death after trophic factor withdrawal. The ability to inhibit neuronal death by manipulating the Bcl-2 or the ICE-family proteins demonstrates the importance of these proteins in the neuronal apoptotic pathway. The utility of inhibiting neuronal death by blocking the apoptotic pathway as therapy in neuropathological situations is discussed.

Citations

Sep 13, 2001·Molecular Reproduction and Development·A L KeimK H Moley
Apr 17, 2008·Journal of Molecular Histology·Katarina VukojevicMirna Saraga-Babic
Jan 29, 2000·Brain Research. Developmental Brain Research·P NikolicP R Thorne
Nov 19, 2002·Neuroscience·J W McdonaldD W Choi
Jan 5, 2002·Bioorganic & Medicinal Chemistry Letters·Chikara MurakataRobert L Hudkins
Sep 1, 1997·Nature Medicine·D M Holtzman, M Deshmukh
Oct 2, 2002·Journal of Neurochemistry·Amos BodnerRichard J Miller
Jan 3, 2001·Pediatric Research·R A ApakN Cakar
Jun 25, 2009·The Journal of Reproduction and Development·Xing-Hui ShenNam-Hyung Kim
Oct 25, 2008·The Journal of Endocrinology·S SchmidtA Schürmann
Sep 23, 1998·The Journal of Cell Biology·S J NeameK L Philpott
Nov 14, 2015·Cell Death and Differentiation·R A Lockshin
Mar 10, 2001·Reviews in the Neurosciences·K M Giehl
Aug 5, 1998·The American Journal of Physiology·K H MoleyM M Mueckler
Aug 31, 2000·Neurobiology of Disease·J S Gill, A J Windebank

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