PMID: 9179600Jun 1, 1997Paper

Neuronal dependency of the glycine transporter GLYT1 expression in glial cells

Glia
Francisco ZafraCecilio Giménez

Abstract

Two membrane-localized transporter proteins (GLYT1 and GLYT2) are responsible for removal of extracellular glycine in the mammalian CNS. Whereas GLYT1 seems to be expressed mainly in glial cells, GLYT2 is neuronal. The highest concentrations of both transporters are found in glycinergic areas of the nervous system. The expression of these proteins may be under regulatory control. We demonstrate here that GLYT1 is not expressed in pure glial cultures, but it is expressed by diverse types of glial cells in mixed neuronal/glial cultures. In these mixed cultures, the glial expression of GLYT1 is down-regulated after selective elimination of the neurons. The absence of expression in pure glial cultures and the observed reduction in the GLYT1 expression after neuronal loss support the existence of a regulatory cross-talk between neurons and glia to initiate and sustain the glial expression of GLYT1.

References

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Citations

Nov 13, 2003·European Journal of Pharmacology·Carmen Aragón, Beatriz López-Corcuera
Oct 13, 2001·Brain Research. Molecular Brain Research·Y SakataS Kure
Dec 5, 1997·Brain Research. Molecular Brain Research·I PoyatosF Zafra
Mar 15, 2001·Neurochemistry International·D V Pow
May 23, 2001·Progress in Neurobiology·N C Danbolt
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H FujitaM Sakanaka
Oct 2, 2002·FEBS Letters·Stéphane Supplisson, Michel J Roux
Sep 19, 2008·IUBMB Life·Francisco Zafra, Cecilio Giménez
Dec 31, 2005·Journal of Neurophysiology·Weifeng SongLori L McMahon
Mar 23, 2006·The Journal of Biological Chemistry·Elena KartvelishvilyHerman Wolosker
Sep 25, 2014·Biomedit︠s︡inskai︠a︡ khimii︠a︡·V N Nikandrov, T V Balashevich
Apr 25, 2001·Journal of Neuroscience Research·A Gadea, A M López-Colomé
Mar 6, 2002·Journal of Neurophysiology·Siriporn C Chattipakorn, Lori L McMahon
Jul 28, 2020·Neuroscience and Biobehavioral Reviews·Bruno Lemes MarquesMauro Cunha Xavier Pinto

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