Neuronal detection thresholds during vestibular compensation: contributions of response variability and sensory substitution

The Journal of Physiology
Mohsen JamaliKathleen E Cullen

Abstract

The vestibular system is responsible for processing self-motion, allowing normal subjects to discriminate the direction of rotational movements as slow as 1-2 deg s(-1). After unilateral vestibular injury patients' direction-discrimination thresholds worsen to ∼20 deg s(-1), and despite some improvement thresholds remain substantially elevated following compensation. To date, however, the underlying neural mechanisms of this recovery have not been addressed. Here, we recorded from first-order central neurons in the macaque monkey that provide vestibular information to higher brain areas for self-motion perception. Immediately following unilateral labyrinthectomy, neuronal detection thresholds increased by more than two-fold (from 14 to 30 deg s(-1)). While thresholds showed slight improvement by week 3 (25 deg s(-1)), they never recovered to control values - a trend mirroring the time course of perceptual thresholds in patients. We further discovered that changes in neuronal response variability paralleled changes in sensitivity for vestibular stimulation during compensation, thereby causing detection thresholds to remain elevated over time. However, we found that in a subset of neurons, the emergence of neck proprioceptive res...Continue Reading

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Citations

Sep 9, 2015·Frontiers in Systems Neuroscience·Ajitkumar P MulavaraJacob J Bloomberg
Apr 17, 2016·Journal of Neurology·Hans StrakaKathleen E Cullen
Jan 24, 2018·Journal of Neurophysiology·Bart B G T AlbertsW Pieter Medendorp
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Oct 28, 2016·Nature Communications·Mohsen JamaliKathleen E Cullen
Jan 31, 2019·Journal of Neurophysiology·Bart B G T AlbertsW Pieter Medendorp
Mar 28, 2019·Nature Reviews. Neuroscience·Kathleen E Cullen
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Jul 12, 2021·Progress in Neurobiology·Justine FacchiniYoh'i Zennou-Azogui
Dec 13, 2018·Audiology & Neuro-otology·Dominique VibertMarco Caversaccio

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