Neuronal evidence for individual eye control in the primate cMRF

Progress in Brain Research
David M WaitzmanKathleen E Cullen

Abstract

Previous single unit recordings and electrical stimulation have suggested that separate regions of the MRF participate in the control of vergence and conjugate eye movements. Neurons in the supraoculomotor area (SOA) have been found to encode symmetric vergence [Zhang, Y. et al. (1992). J. Neurophysiol., 67: 944-960] while neurons in the central MRF, the cMRF, located ventral to the SOA and lateral to the oculomotor nucleus are associated with conjugate eye movements [Waitzman, D.M. et al. (1996). J. Neurophysiol., 75(4): 1546-1572]. However, it remains unknown if cMRF neurons are strictly associated with conjugate movements since eye movements were recorded with a single eye coil in monkeys viewing visual stimuli at a distance of at least 50 cm. In the current study we addressed whether neurons in the cMRF might also encode vergence-related information. Interestingly, electrical stimulation elicited disconjugate saccades (contralateral eye moved more than the ipsilateral eye) from locations previously thought to elicit only conjugate saccades. Single unit recordings in this same area made in two rhesus monkeys trained to follow visual stimuli moved rapidly in depth along the axis of sight of an individual eye demonstrate that ...Continue Reading

Citations

Oct 19, 2012·Journal of Neurophysiology·K P Schultz, C Busettini
Dec 19, 2013·Investigative Ophthalmology & Visual Science·Mark M G WaltonMichael Mustari
May 11, 2016·Neurology·Muhammad Bilal AbidLeonard L L Yeo
Oct 21, 2016·Frontiers in Systems Neuroscience·Chien-Cheng ChenMelody Ying-Yu Huang
Apr 14, 2017·Journal of Neurophysiology·Mark M G WaltonKristina Tarczy-Hornoch
Jul 18, 2008·Journal of Neurophysiology·Marion R Van Horn, Kathleen E Cullen
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May 1, 2009·Journal of Neurophysiology·Marion R Van Horn, Kathleen E Cullen
Jul 8, 2020·Investigative Ophthalmology & Visual Science·Paul J May, Paul D Gamlin
Jun 8, 2011·The European Journal of Neuroscience·Kathleen E Cullen, Marion R Van Horn
Nov 17, 2017·Journal of Neurophysiology·Adam C PallusMichael J Mustari
Dec 26, 2019·Brain Structure & Function·Paul J MayJonathan T Erichsen
Nov 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Julie QuinetPaul D Gamlin

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