Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke.

Brain Research
Carmen M CirsteaWilliam M Brooks

Abstract

Whether functional changes of the non-primary motor areas, e.g., dorsal premotor (PMd) and supplementary motor (SMA) areas, after stroke, reflect reorganization phenomena or recruitment of a pre-existing motor network remains to be clarified. We hypothesized that cellular changes in these areas would be consistent with their involvement in post-stroke reorganization. Specifically, we expected that neuronal and glial compartments would be altered in radiologically normal-appearing, i.e., spared, PMd and SMA in patients with arm paresis. Twenty survivors of a single ischemic subcortical stroke and 16 age-matched healthy controls were included. At more than six months after stroke, metabolites related to neuronal and glial compartments: N-acetylaspartate, myo-inositol, and glutamate/glutamine, were quantified by proton magnetic resonance spectroscopy in PMd and SMA in both injured (ipsilesional) and un-injured (contralesional) hemispheres. Correlations between metabolites were also calculated. Finally, relationships between metabolite concentrations and arm motor impairment (total and proximal Fugl-Meyer Upper Extremity, FMUE, scores) were analyzed. Compared to controls, stroke survivors showed significantly higher ipsilesional PM...Continue Reading

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Citations

Jun 4, 2016·Restorative Neurology and Neuroscience·Paul W JonesLara A Boyd
Mar 18, 2017·Journal of Neurosurgery. Spine·Sorin C CraciunasCarmen M Cirstea
Apr 13, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jennifer K FerrisLara A Boyd
Nov 23, 2021·Frontiers in Neuroscience·Anna Maria CorteseGiovanni Pellegrino

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