PMID: 6113032May 25, 1981Paper

Neuronal, glial and meningeal localizations of neurotransmitter-sensitive adenylate cyclases in cerebral cortex of mice

Brain Research
C EbersoltJ Bockaert

Abstract

The neurotransmitter-sensitive adenylate cyclases, respectively present in the dissociated cells of new-born mouse cerebral cortex (containing both neuronal and glial cells) and in a homogeneous population of glial cells, were compared. The dissociated cells from the cerebral cortex of new-born mice were found to contain Ca2+-, dopamine-, serotonin- and purinergic-sensitive adenylate cyclases. The dopaminergic receptor involved was extensively characterized and was similar to that described in adult animals. Beta-adrenergic-sensitive adenylate cyclase was present but was poorly active. After 3 weeks in culture, the neurons disappeared and a homogeneous population of glial cells was obtained (96% of the cells synthetized glial fibrillary acidic protein). These glial cells contained a highly potent beta-adrenergic-sensitive adenylate cyclase, and adenosine- adn Ca2+-sensitive enzymes. Ca2+ stimulation of the adenylate cyclase was due to the presence of calmodulin. We suggested that the dopaminergic- and serotoninergic-sensitive adenylate cyclases which disappeared during culture are probably localized in neuronal cells. The presence of Ca2+-, adenosine- and beta-adrenergic-sensitive adenylate cyclases in glial cells does not excl...Continue Reading

References

Jul 1, 1977·Archives of Biochemistry and Biophysics·P D KanofP Greengard
Aug 1, 1979·Neurochemical Research·J BardakdjianP Gonnard
Dec 29, 1978·Biochemical and Biophysical Research Communications·G Labourdette, P Mandel
Dec 17, 1976·Brain Research·E G McGeerP L McGeer
Apr 1, 1974·Analytical Biochemistry·Y SalomonM Rodbell

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Citations

Mar 1, 1983·Cellular and Molecular Neurobiology·H K Kimelberg
Oct 1, 1989·Brain Research. Brain Research Reviews·E A Stone, M A Ariano
Sep 1, 1991·Neurobiology of Aging·H M Wisniewski, J Wegiel
Apr 1, 1993·Progress in Neurobiology·E Hösli, L Hösli
Aug 1, 1987·Neuroscience·S Murphy, B Pearce
Apr 4, 1997·Molecular and Cellular Endocrinology·J HanouneN Defer
Jan 1, 1994·British Journal of Pharmacology·M C Peakman, S J Hill
Jan 1, 1988·Annals of the New York Academy of Sciences·A Prochiantz, M Mallat
Jan 1, 1985·Journal of Cellular Physiology·D K WuJ de Vellis
Jan 1, 1981·Journal of Neuroscience Research·C EbersoltJ Bockaert

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