PMID: 9185674May 23, 1997Paper

Neuronal inclusions in the dentate fascia in patients with multiple system atrophy

Neuroscience Letters
A TakedaM Oda

Abstract

Ubiquitin-immunoreactive neuronal inclusions in the granular cells in the dentate fascia (UNIDs) of patients with multiple system atrophy (MSA) were examined for immunohistochemical and ultrastructural characterization especially in comparison with those which were recently reported for amyotrophic lateral sclerosis with dementia (ALS-D). Eight of 23 MSA patients had UNIDs which were also identified by Gallyas-Braak impregnation but immunonegative for other antibodies including against tau, neurofilaments, and alphaB crystallin. Ultrastructurally, loosely aggregated fibrils without limiting membrane located around the nucleus, which was confirmed by the results of ubiquitin-immunoelectron microscopy. The formation of UNIDs in MSA and ALS-D was suggested to be caused by different types of degeneration because UNIDs in MSA differ from these in ALS-D in terms of their stainability by Gallyas-Braak impregnation and ultrastructurally. In this study hippocampal involvement in MSA differing from ALS-D was clarified.

References

Sep 1, 1990·Journal of Neuropathology and Experimental Neurology·Y NakazatoH Yamaguchi

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Citations

Apr 29, 1998·Journal of the Neurological Sciences·K WakabayashiH Takahashi
Jun 5, 2003·Neurotoxicology·G Jean Harry, Christian Lefebvre d'Hellencourt
Oct 23, 2001·Neuropathology : Official Journal of the Japanese Society of Neuropathology·T YokoyamaS Yagishita
Sep 12, 2006·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Koichi Wakabayashi, Hitoshi Takahashi
Jul 30, 2010·Journal of the Neurological Sciences·Kouki MakiokaKoichi Okamoto
May 20, 2015·Brain : a Journal of Neurology·Matthew D CykowskiJoseph E Parisi
Jan 24, 2007·Neuropathology and Applied Neurobiology·B SikorskaH Budka
Sep 27, 2000·Journal of Neuropathology and Experimental Neurology·J E DudaJ Q Trojanowski
Apr 19, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Mari SaitoSatoshi Kamei
Feb 26, 2020·Translational Neurodegeneration·Seiji KajiRyosuke Takahashi
Jun 3, 2021·International Journal of Molecular Sciences·Panagiota Mavroeidi, Maria Xilouri
Jul 2, 2021·Brain Pathology·Fumiaki MoriKoichi Wakabayashi

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