Neuronal localization of CD38 antigen in the human brain

Brain Research
M MizuguchiK Ikeda

Abstract

CD38 is a lymphocyte differentiation antigen which is involved in the cyclic ADP-ribose-mediated second messenger system. We provide immunochemical and immunohistochemical evidence for the expression of CD38 in the adult human brain. We used six polyclonal antibodies against synthetic CD38 polypeptides, in addition to four monoclonal antibodies already available. Brain CD38 was detectable by Western blotting after immunoaffinity purification of the brain extracts. Immunoperoxidase staining localized CD38 immunoreactivity to the perikarya and dendrites of many neurons, such as the cerebellar Purkinje cells, implying that CD38 is involved in the signal transduction within the central nervous system neurons.

References

Oct 1, 1992·Neuroscience Research·S NakanishiK Mikoshiba
Jan 1, 1992·International Journal of Clinical & Laboratory Research·F MalavasiS Roggero
Jun 27, 1994·Brain Research·M MizuguchiS Kamoshita
Jul 15, 1994·Biochemical and Biophysical Research Communications·Q LiY Seino
Mar 1, 1994·Immunology Today·F MalavasiK Mehta
Jan 15, 1993·Science·A Galione
Sep 30, 1993·Nature·M J Berridge

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Citations

Feb 23, 2020·Cells·Serge GuerreiroDamien Toulorge
May 31, 2020·Cardiovascular Drugs and Therapy·Wanyun ZuoQiming Liu
Dec 5, 1997·Cell Biochemistry and Biophysics·H C Lee
Feb 24, 2001·Journal of Neurochemistry·H HigashidaT Kato
Mar 14, 2008·International Journal of Immunopathology and Pharmacology·M OrcianiR Di Primio
Mar 5, 2009·Journal of Neurotrauma·Ayelet LevyLior Mayo
Sep 9, 2011·IUBMB Life·Felipe Vences-Catalán, Leopoldo Santos-Argumedo
Dec 11, 2013·Translational Stroke Research·Katrina OwensTibor Kristian
Jan 26, 2000·Journal of Neurochemistry·T HottaH Higashida
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·H C Lee
Aug 12, 2003·The Journal of Biological Chemistry·Claire CeniMarie-Jo Moutin
Oct 28, 2004·Journal of Endocrinological Investigation·A Antonelli, E Ferrannini
Apr 22, 2015·Annals of Neurology·Eran BlacherAyelet Levy
Dec 29, 2019·Cells·Haruhiro HigashidaOlga Lopatina
Jul 15, 2020·Journal of Clinical Medicine·Xiang ZhouSophia Danhof
May 12, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M MorraF Malavasi
Dec 12, 2001·Clinical and Experimental Immunology·A AntonelliE Ferrannini
Feb 16, 2021·Frontiers in Molecular Biosciences·Katharine Nichole HolmPaul J Hagerman
Jun 19, 2018·Best Practice & Research. Clinical Haematology·Sophia DanhofEric L Smith
Mar 5, 1999·Brain Research·K M Khoo, C F Chang
Jan 4, 2001·Leukemia Research·S DeaglioF Malavasi
Jan 23, 1998·The International Journal of Biochemistry & Cell Biology·A De FloraE Zocchi
Oct 29, 2003·Biochimica Et Biophysica Acta·Jean-Jacques LacapèrePhilippe Deterre
Aug 1, 2007·Neurochemistry International·Haruhiro HigashidaMami Noda

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