PMID: 15328607Aug 27, 2004Paper

Neuronal MAP2 mRNA: species-dependent differential dendritic targeting competence

Journal of Molecular Biology
Massimiliano CristofanilliHenri Tiedge

Abstract

Providing the basis for local protein synthesis in dendritic microdomains, RNA transport in dendrites is thought to be underlying long-term neuronal plasticity. Dendritic RNA targeting mechanisms can therefore be expected to confer selective advantages in the evolution of complex neural systems. The question thus arises as to when and how dendritically targeted transcripts first acquired their targeting competence. To address this question, the dendritic targeting competence of MAP2 transcripts was examined in chicken, mouse and rat. In one approach, we established the somato-dendritic distribution of MAP2 transcripts in vivo. We found that in contrast to rodent MAP2 mRNAs, which are highly enriched in dendritic regions of the retina, chicken MAP2 transcripts are virtually absent from such areas and are rather confined to neuronal somata. In an independent line of investigation, we determined that a dendritic targeting element (DTE) corresponding to the mammalian MAP2 DTE is not contained in the 3' untranslated region (UTR) of avian MAP2 mRNA. The combined results indicate that in contrast to mammalian MAP2 transcripts, avian MAP2 mRNA is lacking dendritic targeting competence. The data thus suggest that the acquisition of such...Continue Reading

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Citations

Sep 21, 2011·Molecular and Cellular Biology·Taesun EomHenri Tiedge
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Stefan KindlerHenri Tiedge
May 21, 2014·The Journal of Cell Biology·Ilham A MuslimovHenri Tiedge
Apr 25, 2009·IUBMB Life·Sanjoy K Bhattacharya
Feb 6, 2008·Aging Cell·Sanjoy K BhattacharyaVera L Bonilha
Nov 25, 2014·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Yongping FanKangning Li
Dec 19, 2013·Stem Cells International·Shahrul Hisham Zainal AriffinMohamad Abdul Razak
Jun 3, 2015·Advanced Healthcare Materials·Madhumita PatelByeongmoon Jeong

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