Neuronal Migration and AUTS2 Syndrome

Brain Sciences
Kei Hori, Mikio Hoshino

Abstract

Neuronal migration is one of the pivotal steps to form a functional brain, and disorganization of this process is believed to underlie the pathology of psychiatric disorders including schizophrenia, autism spectrum disorders (ASD) and epilepsy. However, it is not clear how abnormal neuronal migration causes mental dysfunction. Recently, a key gene for various psychiatric diseases, the Autism susceptibility candidate 2 (AUTS2), has been shown to regulate neuronal migration, which gives new insight into understanding this question. Interestingly, the AUTS2 protein has dual functions: Cytoplasmic AUTS2 regulates actin cytoskeleton to control neuronal migration and neurite extension, while nuclear AUTS2 controls transcription of various genes as a component of the polycomb complex 1 (PRC1). In this review, we discuss AUTS2 from the viewpoint of human genetics, molecular function, brain development, and behavior in animal models, focusing on its role in neuronal migration.

References

Aug 13, 2003·The EMBO Journal·Takeshi KawauchiMikio Hoshino
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takashi NaganoMakoto Sato
Apr 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masato YoshizawaMikio Hoshino
Jan 11, 2007·Human Genetics·Vera M KalscheuerReinhard Ullmann
Mar 23, 2007·Journal of Cell Science·Rachel J Buchsbaum
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Francesco BedogniRobert F Hevner
Apr 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Gunter SchumannPaul Elliott
Nov 22, 2011·PLoS Genetics·Santhosh GirirajanEvan E Eichler
Jan 26, 2013·PLoS Genetics·Nir OksenbergNadav Ahituv
Apr 12, 2013·International Journal of Molecular Sciences·Michael P HunterJohn P O'Bryan
Sep 7, 2013·Trends in Genetics : TIG·Nir Oksenberg, Nadav Ahituv
Sep 11, 2014·European Journal of Human Genetics : EJHG·Gea BeundersErik A Sistermans
Oct 28, 2014·International Journal of Molecular Sciences·Bao ZhangSheng-Bin Li
Dec 19, 2014·Nature·Zhonghua GaoDanny Reinberg
Dec 24, 2014·Cell Reports·Kei HoriMikio Hoshino
Mar 26, 2015·Frontiers in Neuroscience·Kazue Muraki, Kenji Tanigaki
Sep 9, 2015·Translational Psychiatry·W MyungD K Kim
Oct 21, 2015·Journal of Neurochemistry·Orly ReinerKozo Kaibuchi

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Citations

Sep 22, 2017·International Journal of Molecular Sciences·Sara Anna BoniniMaurizio Memo
Aug 10, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Guang Yang, Alex Shcheglovitov
Jul 31, 2018·Brain : a Journal of Neurology·Joanna SzczurkowskaLaura Cancedda
Jun 22, 2018·International Journal of Molecular Sciences·Valentina ZamboniGiorgio R Merlo
Nov 10, 2020·Psychiatric Genetics·Antonio Benítez-Burraco
Dec 3, 2020·Cellular and Molecular Life Sciences : CMLS·Britt MossinkNael Nadif Kasri
Dec 22, 2020·American Journal of Medical Genetics. Part a·Beatriz Martinez-DelgadoManuel Posada
Jan 28, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Shigehiro OgataMikio Hoshino
May 21, 2021·Cerebral Cortex·Anthony S CastanzaRobert F Hevner
Jun 3, 2021·Antioxidants·Carla Enrica GallengaPaolo Perri
Aug 25, 2021·Trends in Genetics : TIG·Simone TamburriDiego Pasini
Oct 13, 2021·Molecular Cell·Sanxiong LiuDanny Reinberg
Jun 25, 2020·Developmental Neuroscience·Amita ShresthaOlalekan M Ogundele
Feb 13, 2021·American Journal of Medical Genetics. Part a·Laura GieldonUte Moog

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Methods Mentioned

BETA
immunoprecipitation
nucleotide exchange

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