PMID: 2998526Nov 1, 1985

Neuronal muscarinic receptors attenuate vagally-induced contraction of feline bronchial smooth muscle

British Journal of Pharmacology
L C BlaberJ Maclagan


In anaesthetized cats, stimulation of the vagus nerves produced bradycardia and a bronchoconstriction which was measured as an increase in lung resistance (RL) and a fall in dynamic lung compliance (Cdyn); these effects were abolished by atropine. Gallamine potentiated vagally-mediated changes in RL and Cdyn at doses that blocked muscarinic receptors in the heart and inhibited neuromuscular transmission. (+)-Tubocurarine and suxamethonium did not affect the response of the lung or the heart to vagal stimulation. Bronchoconstriction induced by intravenous acetylcholine was not potentiated by gallamine, indicating that postsynaptic muscarinic receptors in the lung and changes in muscle tone were not involved. Potentiation of vagally-induced bronchoconstriction appears to be due to blockade of inhibitory muscarinic receptors located in the pulmonary parasympathetic nerves innervating both central and peripheral airways. Pilocarpine was an agonist for these neuronal receptors as it inhibited vagally-induced bronchoconstriction at low doses (10 ng to 1 microgram kg-1). The results demonstrate that gallamine is an antagonist and pilocarpine an agonist at neuronal muscarinic receptors which attenuate parasympathetic nerve activity in ...Continue Reading


Apr 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·A D Fryer, J Maclagan
Aug 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·G D'AgostinoH Kilbinger
Jan 1, 1992·Veterinary Research Communications·M YuF J Derksen
May 19, 1989·European Journal of Pharmacology·J C Mak, P J Barnes
Jan 3, 1990·European Journal of Pharmacology·D F Biggs, R C Ladenius
Feb 14, 1991·European Journal of Pharmacology·Z J Yang, D F Biggs
Nov 12, 1991·European Journal of Pharmacology·S ItabashiT Takishima
Jan 21, 1992·European Journal of Pharmacology·C R Killingsworth, N E Robinson
Jan 1, 1990·Molecular Aspects of Medicine·P J Barnes
Jan 1, 1987·Pharmacology & Therapeutics·R G Andersson, N Grundström
Jan 1, 1988·Pharmacology & Therapeutics·F Mitchelson
Jun 1, 1993·Pharmacology & Therapeutics·M P Caulfield
Feb 1, 1993·Pharmacology & Therapeutics·Y D Pendry
Jun 25, 1995·Journal of the Autonomic Nervous System·S MatsumotoT Shimizu
Nov 1, 1988·Trends in Pharmacological Sciences·P J BarnesJ Maclagan
Oct 1, 1990·Trends in Pharmacological Sciences·D B Jacoby, A D Fryer
Dec 29, 1987·Neuroscience Letters·C J van KoppenC A van Ginneken
Apr 2, 2003·Pharmacology & Therapeutics·Fiona R Coulson, A D Fryer
Mar 27, 2003·Pulmonary Pharmacology & Therapeutics·P J KinghamW Graham McLean
Nov 16, 2002·International Immunopharmacology·Yuji TohdaShigenori Nakajima
Jul 1, 1994·The Veterinary Quarterly·R A van NieuwstadtH J Breukink
Jun 1, 1997·The Veterinary Quarterly·R A van NieuwstadtF P Nijkamp
Aug 6, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·D B Jacoby
Sep 1, 1990·British Journal of Pharmacology·P Aas, J Maclagan
May 1, 1993·British Journal of Pharmacology·J GarssenF P Nijkamp
Oct 1, 2009·Neuromodulation : Journal of the International Neuromodulation Society·Thomas J HoffmannPuyun Guo
May 4, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Thomas J HoffmannCharles W Emala
May 26, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Liliana Moreno-VinascoD B Jacoby
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·A D Fryer, D B Jacoby
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·L S OnR W Costello
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·C M EvansA D Fryer
Mar 1, 1993·The American Review of Respiratory Disease·A D Fryer, O A Okanlami
Mar 2, 2013·American Journal of Respiratory Cell and Molecular Biology·Matthew G DrakeD B Jacoby


Jul 1, 1979·British Journal of Pharmacology·J Maclagan, U M Ney
May 1, 1974·Anesthesiology·R W GardierW Hamelberg
Jan 1, 1970·Naunyn-Schmiedebergs Archiv Für Pharmakologie·K Löffelholz, E Muscholl
Nov 1, 1971·Journal of Applied Physiology·G A CabezasJ A NADEL
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·B Libet, T Tosaka
Dec 1, 1974·Journal of Applied Physiology·H J Colebatch, L A Engel
Aug 1, 1983·British Journal of Pharmacology·U M Ney
Nov 1, 1982·The Journal of Physiology·J P GallagherP Shinnick-Gallagher
May 1, 1984·The American Review of Respiratory Disease·N J Gross, M S Skorodin
Dec 1, 1984·British Journal of Pharmacology·A D Fryer, J Maclagan
Jan 1, 1954·The Journal of Physiology·J G WIDDICOMBE
Jan 1, 1954·The Journal of Physiology·J G WIDDICOMBE
Feb 1, 1958·The American Journal of Physiology·M O AMDUR, J MEAD
Feb 1, 1960·The Journal of Physiology·A J BULLERR M ECCLES
Jan 1, 1963·Physiological Reviews·J G WIDDICOMBE

Related Concepts

Airway Resistance
Diastolic Blood Pressure
Synaptic Transmission
Smooth Muscle
Vagus Nerve Structure
Lung Diseases
Lobar Bronchus Structure
Lung Compliance

Related Feeds


Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.