Neuronal network-based mathematical modeling of perceived verticality in acute unilateral vestibular lesions: from nerve to thalamus and cortex

Journal of Neurology
Stefan GlasauerT Brandt

Abstract

Acute unilateral lesions of vestibular graviceptive pathways from the otolith organs and semicircular canals via vestibular nuclei and the thalamus to the parieto-insular vestibular cortex regularly cause deviations of perceived verticality in the frontal roll plane. These tilts are ipsilateral in peripheral and in ponto-medullary lesions and contralateral in ponto-mesencephalic lesions. Unilateral lesions of the vestibular thalamus or cortex cause smaller tilts of the perceived vertical, which may be either ipsilateral or contralateral. Using a neural network model, we previously explained why unilateral vestibular midbrain lesions rarely manifest with rotational vertigo. We here extend this approach, focussing on the direction-specific deviations of perceived verticality in the roll plane caused by acute unilateral vestibular lesions from the labyrinth to the cortex. Traditionally, the effect of unilateral peripheral lesions on perceived verticality has been attributed to a lesion-based bias of the otolith system. We here suggest, on the basis of a comparison of model simulations with patient data, that perceived visual tilt after peripheral lesions is caused by the effect of a torsional semicircular canal bias on the central...Continue Reading

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Citations

Nov 22, 2018·Current Opinion in Neurology·Thomas Brandt, Marianne Dieterich
Mar 19, 2019·Journal of Neurologic Physical Therapy : JNPT·Daniel R Gold, Michael C Schubert
May 14, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K MöhwaldA Zwergal
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Sep 7, 2018·Journal of Neurology·Kwang-Dong Choi, Ji-Soo Kim
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Aug 28, 2020·Frontiers in Neurology·Andreas ZwergalMarianne Dieterich
Apr 20, 2019·Frontiers in Neurology·Marianne Dieterich, Thomas Brandt
Oct 11, 2020·Diagnostics·Daniel Rodríguez-AlmagroAlexander Achalandabaso-Ochoa
Dec 4, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Bernhard BaierMarianne Dieterich
Jan 31, 2021·Scientific Reports·Florian SchöberlAndreas Zwergal
Jul 24, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Kemar E Green, Daniel R Gold
Nov 23, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Bernhard BaierMarianne Dieterich

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