Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation.

Journal of Neuroinflammation
Lorise C GahringScott W Rogers

Abstract

A major site of initiation of inflammatory responses upon physical perturbation(s) and infection by invading organisms is the skin. Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor (nAChR) alpha7. To further investigate the role of alpha7 in skin inflammatory responses, a local inflammatory response was induced by topical application of croton oil to the ear skin of wild-type (alpha7WT) and alpha7 knock-out (alpha7KO) mice. Cells infiltrating the inflamed tissue were characterized by flow cytometry and RNA analysis. Six hours following croton oil application, analysis of infiltrating cells showed that the alpha7KO mice exhibited a significantly enhanced number of cells, and specifically, of Ly6G positive neutrophils. Macrophage and lymphocyte infiltration was equivalent in the alpha7KO and alpha7WT mice. RNA analysis showed that IL-1beta and IL-6 were increased significantly in the infiltrating cells of the alpha7KO mouse, although TNF failed to reach significance. In contrast, resident cells of the skin exhibited no differences in these cytokines between genotypes. Both resident and infiltrating cell populations from alpha7KO mice did show elevated message levels for th...Continue Reading

References

Apr 1, 1978·Plastic and Reconstructive Surgery·L H MoselyM Goody
Jan 1, 1991·Annual Review of Immunology·M L Dustin, T A Springer
Apr 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·H KlapprothI Wessler
Aug 1, 1997·The Journal of Investigative Dermatology. Symposium Proceedings·S A Grando
Sep 29, 1999·Gastroenterology·F GaleazziS M Collins
Nov 5, 1999·Alcoholism, Clinical and Experimental Research·L C GahringS W Rogers
Apr 27, 2000·Current Opinion in Immunology·J J Campbell, E C Butcher
Aug 25, 2000·European Journal of Gastroenterology & Hepatology·D T Rubin, S B Hanauer
Nov 24, 2001·Archives of Disease in Childhood·P DaviesD Martinez
Jan 5, 2002·The American Journal of Gastroenterology·S A NaserH Miles
Feb 1, 2002·Nature Medicine·Bernhard HomeyAlbert Zlotnik
Feb 5, 2002·Immunity·Eric J Kunkel, Eugene C Butcher
Oct 23, 2002·The Journal of Cell Biology·Juan ArredondoSergei A Grando
Mar 12, 2003·Life Sciences·Ignaz WesslerCharles James Kirkpatrick
Apr 16, 2003·Molecular Pharmacology·Ramiro SalasMariella De Biasi
Mar 17, 2004·Experimental Cell Research·Vu Thuong NguyenSergei A Grando
Mar 23, 2004·Annual Review of Immunology·Antal Rot, Ulrich H von Andrian
May 13, 2004·Clinical and Diagnostic Laboratory Immunology·Roma KalraMohan L Sopori
Oct 16, 2004·The Journal of Investigative Dermatology·Hjalmar KurzenMartin Deichmann
Oct 21, 2004·The Cochrane Database of Systematic Reviews·J McGrathJ K Macdonald
Oct 27, 2004·Experimental Dermatology·Laurent Misery
Feb 8, 2006·Annals of the New York Academy of Sciences·Margot Gallowitsch-Puerta, Kevin J Tracey
Mar 4, 2006·Experimental Dermatology·Sergei A Grando
Apr 6, 2006·The AAPS Journal·Lorise C Gahring, Scott W Rogers
Apr 29, 2006·The Journal of Investigative Dermatology·Itay KlazSarah Brenner
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Bernhard HomeyDonald Y M Leung
Nov 17, 2006·Journal of Leukocyte Biology·Isabelle Cloëz-Tayarani, Jean-Pierre Changeux
Apr 14, 2007·American Journal of Respiratory Cell and Molecular Biology·Xiao SuMichael A Matthay
May 16, 2007·British Journal of Pharmacology·W J de Jonge, L Ulloa
Jun 15, 2007·The Journal of Allergy and Clinical Immunology·Margaret KellyPaul Kubes
Sep 22, 2007·Annual Review of Pharmacology and Toxicology·Antonella Viola, Andrew D Luster
Nov 21, 2007·Clinics in Dermatology·Brian J NickoloffJian-Zhong Qin
Dec 14, 2007·Journal of Neuroimmunology·Amber V Osborne-HerefordLorise C Gahring
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Antonella ViolaRita Lucia Contento
Jul 17, 2008·The Journal of Infectious Diseases·Ilona A J GiebelenTom van der Poll
Jan 8, 2009·Physiological Reviews·Edson X AlbuquerqueScott W Rogers
Feb 28, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ralph S CaraballoKatherine Asman
Jun 6, 2009·Journal of Internal Medicine·M Rosas-Ballina, K J Tracey

❮ Previous
Next ❯

Citations

Aug 21, 2013·Biochemical Pharmacology·Iboro C UmanaDaniel S McGehee
Feb 9, 2016·Autoimmunity Reviews·Anantha Maharasi RamaKrishnan, Kavitha Sankaranarayanan
Jan 11, 2011·Journal of Clinical Periodontology·John B MatthewsIain L C Chapple
Mar 8, 2013·Dermato-endocrinology·Alex I ChernyavskySergei A Grando
Apr 15, 2018·Acta Parasitologica·Fabiola Del Rocío Villalobos-GómezJavier Ventura-Juárez
May 20, 2020·Antimicrobial Agents and Chemotherapy·Jie HeAnna R Huppler

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
cell
reverse transcription PCR
PCR

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.