Neuronal nitric oxide strongly suppresses sympathetic outflow in high-salt Dahl rats

Journal of Hypertension
Yasuhiro NishidaJouji Horiuchi

Abstract

To investigate the effects of a selective inhibitor of neuronal nitric oxide synthase (nNOS), 7-nitroindazole, on peripheral sympathetic outflow in Dahl rats. Dahl salt-sensitive and salt-resistant rats were fed either a regular-salt (0.4% NaCl) or a high-salt (8% NaCl) diet for 4 weeks. In chronically instrumented conscious rats, renal sympathetic nerve activity (RSNA) was measured in both baroreceptor-loaded and baroreceptor-unloaded states. The baroreceptor unload was performed by decreasing arterial pressure with occlusion of the inferior vena cava. 7-Nitroindazole (307 micromol/kg intraperitoneally) increased resting RSNA from 24 +/- 3% to 38 +/- 6% with an increase in mean arterial pressure of 15 +/- 3 mmHg, and increased baroreceptor-unloaded RSNA from 100% to 278 +/- 16% in salt-sensitive Dahl rats receiving a high-salt diet However, 7-nitroindazole did not increase resting RSNA, but did increase baroreceptor-unloaded RSNA from 100% to 179 +/- 15%, 177 +/- 15%, and 133 +/- 4% in salt-sensitive Dahl rats receiving a regular-salt diet, salt-resistant Dahl rats receiving a high-salt diet, and salt-resistant Dahl rats receiving a regular-salt diet, respectively. The high-salt diet significantly increased the baroreceptor-un...Continue Reading

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Citations

Feb 4, 2012·The Journal of Physiological Sciences : JPS·Yasuhiro NishidaKohsuke Hagisawa
Jul 30, 2002·Autonomic Neuroscience : Basic & Clinical·J Zanzinger
Feb 5, 2013·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Yasuhiro NishidaKohsuke Hagisawa
Jun 6, 2016·The Journal of Physiological Sciences : JPS·Yasuhiro NishidaHidetake Yokoe
Mar 19, 2005·Journal of Hypertension·Megumi Tandai-HirumaYasuhiro Nishida
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Nov 6, 2007·American Journal of Physiology. Renal Physiology·Matthew E PattersonKenneth D Mitchell
Aug 1, 2012·Physiological Research·J ZichaJ Kuneš

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