Neuronal nitric oxide synthase immunoreactivity in the guinea-pig liver: distribution and colocalization with neuropeptide Y and calcitonin gene-related peptide

Liver
F J EstebanM A Peinado

Abstract

The innervation pattern of the guinea-pig liver is similar to that of the human liver. However, many aspects of the distribution of the neuronal isoform of the enzyme nitric oxide synthase (nNOS) in the guinea-pig liver and its colocalization with neuropeptides remain to be elucidated. The distribution of nNOS was studied in fixed guinea-pig liver by light microscopic immunohistochemistry. Confocal analysis was used to determine its colocalization with neuropeptide Y (NPY) or calcitonin gene-related peptide (CGRP). nNOS-immunoreactive (nNOS-IR) nerves were observed in relation to hilar and interlobar vessels and in Glisson's capsule. A few nNOS-IR ganglia were observed in the extrahepatic bile duct and close to the interlobar portal triads. In addition, nNOS-IR fibers were located in the interlobular portal triads and pervading the parenchyma. Moreover, nNOS-IR nerves were demonstrated for the first time in the larger central veins and in the hepatic vein. nNOS-NPY and nNOS-CGRP colocalizations were detected in the fibromuscular layer of the bile duct and periductal plexus, respectively. These results support the phylogenetic conservation of the nNOS-IR hepatic innervation and its possible contribution to the regulation of hepa...Continue Reading

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Citations

Sep 21, 2002·Autonomic Neuroscience : Basic & Clinical·María A PeinadoFrancisco J Esteban
Feb 27, 2003·Journal of Gastroenterology and Hepatology·Hiroshi Kaneko
May 4, 2006·Pancreas·Ernesto Hernández-BarbáchanoJosé Julián Calvo
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Robert S McCuskey
Mar 24, 2015·Progress in Retinal and Eye Research·Ana Santos-CarvalhoCláudia Cavadas
Aug 20, 2005·Pharmacological Reviews·Noboru Toda, Arnold G Herman
Oct 24, 2014·Pflügers Archiv : European journal of physiology·Noboru Toda, Tomio Okamura

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