Neuronal pathways linking substance P to drug addiction and stress.

Brain Research
K G Commons

Abstract

Accumulating evidence suggests that the neuropeptide substance P (SP) and its principal receptor neurokinin 1 (NK1) play a specific role in the behavioral response to opioids and stress that may help to initiate and maintain addictive behavior. In animal models, the NK1 receptor is required for opioids to produce their rewarding and motivational effects. SP neurotransmission is also implicated in the behavioral response to stress and in the process of drug sensitization, potentially contributing to vulnerability to addiction or relapse. However, SP neurotransmission only plays a minor role in opioid-mediated antinociception and the development of opioid tolerance. Moreover, the effects of SP on addiction-related behavior are selective for opioids and evidence supporting a role in the response to cocaine or psychostimulants is less compelling. This review will summarize the effects of SP neurotransmission on opioid-dependent behaviors and correlate them with potential contributing neural pathways. Specifically, SP neurotransmission within components of the basal forebrain particularly the nucleus accumbens and ventral pallidum as well as actions within the ascending serotonin system will be emphasized. In addition, cellular- or ...Continue Reading

References

Jul 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·V M PickelD J Reis
Jun 28, 1992·Annals of the New York Academy of Sciences·K A CunninghamN E Goeders
Jan 1, 1992·Life Sciences·E J BilskyL D Reid
Jan 1, 1991·Psychopharmacology·W A Corrigall, K M Coen
Aug 27, 1986·Brain Research·P J Elliott, S D Iversen
Mar 1, 1974·Psychological Review·R L Solomon, J D Corbit
Jan 1, 1980·Annual Review of Neuroscience·R A NicollS E Leeman
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·B M VelimirovicY Nakajima
Sep 23, 1994·Science·A M GraybielM Kimura
Jul 1, 1995·Canadian Journal of Physiology and Pharmacology·J Culman, T Unger
Jan 16, 1998·European Journal of Pharmacology·T L Sills, P J Fletcher
May 29, 1999·Critical Reviews in Neurobiology·T S Shippenberg, G I Elmer
Jul 23, 1999·Annals of the New York Academy of Sciences·G F Koob
Oct 26, 1999·Trends in Neurosciences·R Spanagel, F Weiss
Jun 29, 2000·Trends in Pharmacological Sciences·R Hill
Feb 13, 2001·Journal of Internal Medicine·T HökfeltJ Wahren
Apr 23, 2002·The Journal of Comparative Neurology·Kathryn G Commons, Rita J Valentino
Sep 13, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rongjian LiuGeorge K Aghajanian
Oct 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert T FremeauRobert H Edwards
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sondra T BlandSteven F Maier
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Karl EbnerNicolas Singewald
May 26, 2004·Physiology & Behavior·Kent C Berridge

❮ Previous
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Citations

Jan 5, 2011·Archives of General Psychiatry·Igor ElmanDavid Borsook
Jan 30, 2010·Psychopharmacology·Annika ThorsellMarkus Heilig
Dec 14, 2011·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Megan E PiperTimothy B Baker
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Estelle BarbierMarkus Heilig
Aug 24, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael T StefanikPeter W Kalivas
Dec 22, 2012·Journal of Molecular Endocrinology·Roger López-BellidoRaquel E Rodríguez
Jun 23, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Pamela LyonJohn Quintner
Sep 26, 2014·Expert Opinion on Drug Discovery·Chris P Bailey, Stephen M Husbands
Mar 27, 2013·Neuroscience·Roger López-BellidoRaquel Emilia Rodríguez
May 21, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mark J MillanGuillaume de Nanteuil
Jan 22, 2013·Journal of Neuroscience Research·Venkata Siva Sai Sujith SajjaPamela VandeVord
Oct 15, 2014·The Journal of Comparative Neurology·Paolo BarbaresiSanto Gratteri
Oct 16, 2012·Drug and Alcohol Dependence·Jonathan L MelamedMarilia Barros
Aug 16, 2012·Social Psychiatry and Psychiatric Epidemiology·Claudia CooperPaul Bebbington
Feb 15, 2013·The International Journal of Neuropsychopharmacology·Kanako SajiHidenori Suzuki
Nov 8, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Timothy M BarrowLiqiong Guo
Nov 1, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jesse R SchankJason P Schroeder
May 13, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sally I SharpHugh M D Gurling
Dec 28, 2017·PloS One·Benjamin HertlerAndreas Rüdiger Luft
Jun 7, 2021·Behavioural Brain Research·Maria M Ortiz-JuzaJose Rodriguez-Romaguera

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