Neuronal Pentraxin 1 Promotes Hypoxic-Ischemic Neuronal Injury by Impairing Mitochondrial Biogenesis via Interactions With Active Bax[6A7] and Mitochondrial Hexokinase II.

ASN Neuro
Md Al RahimMir Ahamed Hossain

Abstract

Mitochondrial dysfunction is a key mechanism of cell death in hypoxic-ischemic brain injury. Neuronal pentraxin 1 (NP1) has been shown to play crucial roles in mitochondria-mediated neuronal death. However, the underlying mechanism(s) of NP1-induced mitochondrial dysfunction in hypoxia-ischemia (HI) remains obscure. Here, we report that NP1 induction following HI and its subsequent localization to mitochondria, leads to disruption of key regulatory proteins for mitochondrial biogenesis. Brain mitochondrial DNA (mtDNA) content and mtDNA-encoded subunit I of complex IV (mtCOX-1) expression was increased post-HI, but not the nuclear DNA-encoded subunit of complex II (nSDH-A). Up-regulation of mitochondrial proteins COXIV and HSP60 further supported enhanced mtDNA function. NP1 interaction with active Bax (Bax6A7) was increased in the brain after HI and in oxygen-glucose deprivation (OGD)-induced neuronal cultures. Importantly, NP1 colocalized with mitochondrial hexokinase II (mtHKII) following OGD leading to HKII dissociation from mitochondria. Knockdown of NP1 or SB216763, a GSK-3 inhibitor, prevented OGD-induced mtHKII dissociation and cellular ATP decrease. NP1 also modulated the expression of mitochondrial transcription factor...Continue Reading

References

May 18, 2000·Biochemical Society Transactions·A P HalestrapA O'Toole
Jun 8, 2001·Journal of Neuroscience Methods·C WuK Shimoji
Oct 6, 2001·Stroke; a Journal of Cerebral Circulation·H ChenC Y Hsu
Dec 26, 2001·The Journal of Biological Chemistry·John G PastorinoJan B Hoek
Nov 20, 2002·Circulation·S Gupta, A A Knowlton
Jul 23, 2003·Current Medicinal Chemistry·John G Pastorino, Jan B Hoek
Feb 24, 2004·Molecular and Cellular Biochemistry·Marco Colombini
Feb 24, 2004·Molecular and Cellular Biochemistry·Mikhail Vyssokikh, Dieter Brdiczka
Apr 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mir Ahamed HossainJohn Laterra
Sep 21, 2004·Journal of Bioenergetics and Biomembranes·Henrik Hagberg
Apr 9, 2005·Cell Death and Differentiation·H ZaidV Shoshan-Barmatz
Dec 6, 2005·Journal of Cellular Biochemistry·Richard C Scarpulla
Jan 31, 2006·Free Radical Biology & Medicine·Klas Blomgren, Henrik Hagberg
Dec 22, 2007·Nature Reviews. Molecular Cell Biology·Richard J Youle, Andreas Strasser
Feb 29, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diana R GutsaevaClaude A Piantadosi
Aug 30, 2008·Stroke; a Journal of Cerebral Circulation·Wei YinJun Chen
Nov 27, 2008·The Journal of Biological Chemistry·Alfredo Gimenez-CassinaJavier Diaz-Nido
Dec 17, 2008·Neuron·Mark P MattsonAiwu Cheng
Jun 23, 2009·Nature Reviews. Neuroscience·Lorenzo GalluzziGuido Kroemer
Sep 15, 2009·Biochimica Et Biophysica Acta·Gordon L Rintoul, Ian J Reynolds
Mar 25, 2011·Kidney International·Jonathan M GallSteven C Borkan
Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin B ClaytonRamon Trullas
Oct 17, 2012·Neurobiology of Disease·Md Al RahimMir Ahamed Hossain
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kelley C O'DonnellAlvaro Sagasti

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