PMID: 9183737Jun 5, 1997

Neuronal precursors of the adult rat subependymal zone persist into senescence, with no decline in spatial extent or response to BDNF

Journal of Neurobiology
S A GoldmanH T Thaler


The adult mammalian brain continues to harbor ependymal/subependymal zone (SZ) precursor cells, which can give rise to neurons in vitro. In adult rats, explants of the rostral 6-7 mm of the SZ give rise to neurons in vitro, and over this entire expanse, neuronal survival is supported specifically by brain-derived neurotrophic factor (BDNF). We asked whether either the (a) spatial distribution, (b) abundance, or (c) BDNF responsiveness of the neuronal precursor population was affected by age. Explants of three rostrocaudally defined regions were taken from both young and old rats (3 and 20 months old, respectively), and cultured in 2% fetal bovine serum-containing media with or without added BDNF (20 ng/ml). The extent of neuronal production by these explants varied only minimally with their level of derivation, such that substantial outgrowth was observed at each level tested. Neuronal outgrowth was marginally higher and more rapid in achieving its maximal extent in the 3-month-old rats compared with their aged counterparts, but neuronal outgrowth was robust at each age tested. The duration of survival of SZ-derived neurons did not differ between the young and old rats. At both ages, BDNF supported the survival of these new adu...Continue Reading


Sep 3, 2002·Journal of Neuroscience Research·Philippe Taupin, Fred H Gage
Jun 8, 2001·Journal of Neuroscience Methods·Gregory J BrewerD C McManus
Apr 12, 2002·Brain Research. Developmental Brain Research·Sanjay S P Magavi, Jeffrey D Macklis
Apr 18, 2002·Journal of Neuroimmunology·Paul A FeltsRichard A C Hughes
Apr 8, 1998·Trends in Neurosciences·S A Goldman, M B Luskin
Jan 25, 2003·Experimental Gerontology·Paola ArlottaJeffrey D Macklis
Jan 12, 2002·Current Opinion in Pharmacology·Daniel A Peterson
Apr 24, 2008·Pathology International·Yoshihiro TsutsuiMasaaki Kaneta
Jun 9, 1998·Annals of the New York Academy of Sciences·S A GoldmanS Wang
Apr 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Huang GuoBerislav V Zlokovic
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Jason G EmsleyJeffrey D Macklis
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elodie DrapeauDjoher Nora Abrous
Sep 22, 2007·The European Journal of Neuroscience·S ChiaramelloS De Marchis
Oct 24, 2012·Journal of Biomedical Materials Research. Part a·Zhaoyang YangXiaoguang Li
Jul 28, 2007·Molecular and Cellular Neurosciences·Kevin ChenBronwen Connor
Sep 25, 1999·Seminars in Cell & Developmental Biology·R C Murray, A L Calof
Aug 26, 1998·Journal of Neurobiology·J M García-VerdugoA Alvarez-Buylla
Aug 22, 2006·Journal of Neural Engineering·John C ChangBruce C Wheeler
Mar 25, 2005·Physiological Reviews·Djoher Nora AbrousMichel Le Moal
Dec 7, 2007·Journal of Neuroscience Research·Sulagna Das, Anirban Basu
Apr 3, 2001·Nature Reviews. Neuroscience·A Alvarez-BuyllaA D Tramontin
Jul 4, 1998·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·D G Jones, C M Redpath


Jul 15, 1978·The Journal of Comparative Neurology·R H Nordlander, M Singer
Aug 21, 1992·Brain Research. Developmental Brain Research·S A Goldman, M Nedergaard
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L J RichardsP F Bartlett
May 1, 1992·Behavioral and Neural Biology·T Mencio-WszalekD E Dluzen
Feb 1, 1992·Developmental Biology·M F Marusich, J A Weston
Mar 1, 1991·The American Journal of Psychiatry·M SerbyD Kalkstein
Dec 15, 1990·Brain Research. Developmental Brain Research·K W McDermott, P L Lantos
Feb 13, 1989·Brain Research·F Gómez-PinillaM Nieto-Sampedro
Oct 1, 1988·Brain Research·C Lopez-GarciaI Ferrer
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1986·Biological Psychiatry·M D WarnerJ R Tinklenberg
Sep 1, 1985·The Journal of Comparative Neurology·M S KaplanJ W Hinds
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S A Goldman, F Nottebohm
Dec 10, 1981·The Journal of Comparative Neurology·J W Hinds, N A McNelly
Nov 15, 1980·The Journal of Comparative Neurology·S C BirseR E Coggeshall
Feb 1, 1994·Journal of Neurobiology·M F MarusichJ A Weston
May 1, 1994·Trends in Neurosciences·R M LindsayP S DiStefano
May 1, 1995·Stem Cells·A Alvarez-Buylla, C Lois
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·B Kirschenbaum, S A Goldman
May 20, 1994·Science·C Lois, A Alvarez-Buylla
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C Lois, A Alvarez-Buylla
Jan 12, 1993·Neuroscience Letters·F S CorottoJ A Maruniak
Mar 1, 1993·Neurobiology of Aging·P A LapchakF Hefti
Feb 16, 1996·Science·C LoisA Alvarez-Buylla

Related Concepts

Organ Culture Techniques
Proteins, Recombinant DNA
Brain-Derived Neurotrophic Factor
Cell Survival
Bos indicus
Floating-harbor Syndrome

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.