Neuronal processing of noxious thermal stimuli mediated by dendritic Ca(2+) influx in Drosophila somatosensory neurons

ELife
Shin-Ichiro TeradaTadao Usui

Abstract

Adequate responses to noxious stimuli causing tissue damages are essential for organismal survival. Class IV neurons in Drosophila larvae are polymodal nociceptors responsible for thermal, mechanical, and light sensation. Importantly, activation of Class IV provoked distinct avoidance behaviors, depending on the inputs. We found that noxious thermal stimuli, but not blue light stimulation, caused a unique pattern of Class IV, which were composed of pauses after high-frequency spike trains and a large Ca(2+) rise in the dendrite (the Ca(2+) transient). Both these responses depended on two TRPA channels and the L-type voltage-gated calcium channel (L-VGCC), showing that the thermosensation provokes Ca(2+) influx. The precipitous fluctuation of firing rate in Class IV neurons enhanced the robust heat avoidance. We hypothesize that the Ca(2+) influx can be a key signal encoding a specific modality.

References

Jan 1, 1996·Progress in Brain Research·E R Perl
Feb 4, 2003·Nature Neuroscience·Lei LiuMichael J Welsh
Apr 23, 2003·Cell·W Daniel TraceySeymour Benzer
Jun 20, 2003·Nature·Veena ViswanathTim Jegla
Aug 5, 2003·The Journal of Biological Chemistry·Gabrielle E RieckhofJ Troy Littleton
Dec 9, 2003·Nature Reviews. Neuroscience·Rüdiger Krahe, Fabrizio Gabbiani
Jan 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pablo MonsivaisMichael Häusser
Mar 29, 2006·Nature Neuroscience·Martijn SchonewilleChris I De Zeeuw
Dec 21, 2006·Nature Reviews. Neuroscience·Edward R Perl
Feb 23, 2007·Nature·Ellen A Lumpkin, Michael J Caterina
Dec 7, 2007·Current Biology : CB·Richard Y HwangW Daniel Tracey
Jun 13, 2008·Nature·Fumika N HamadaPaul A Garrity
Jun 14, 2008·Journal of Neurophysiology·Jason W Worrell, Richard B Levine
Jul 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jenny T DavieMichael Häusser
Oct 3, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takaaki SokabeMakoto Tominaga
Dec 17, 2008·Nature Methods·Yasuhiro KameiShunsuke Yuba
Jan 23, 2009·Nature Methods·Marco MankOliver Griesbeck
Apr 21, 2009·Current Biology : CB·Daniel T BabcockMichael J Galko
Jun 3, 2009·Genetics·Jian-Quan NiNorbert Perrimon
Jun 12, 2009·Journal of Neurophysiology·Patrick Sabourin, Gerald S Pollack
Aug 6, 2009·Journal of Computational Neuroscience·Hideaki Shimazaki, Shigeru Shinomoto
Oct 20, 2009·Cell·Allan I BasbaumDavid Julius
Mar 26, 2010·Methods in Molecular Biology·Jason C Caldwell, W Daniel Tracey
Apr 21, 2010·Nature Reviews. Neuroscience·Yuh-Nung Jan, Lily Yeh Jan
May 12, 2010·Journal of Neurophysiology·Kathryn B Grey, Brian D Burrell
Jun 1, 2010·Nature Neuroscience·Marios ChatzigeorgiouWilliam R Schafer
Oct 20, 2010·The Journal of Cell Biology·Ellen A LumpkinAislyn M Nelson
Feb 10, 2011·Nature Reviews. Neuroscience·Patrick DelmasLise Rodat-Despoix
Mar 11, 2011·Human Molecular Genetics·Sergio Casas-TintoPedro Fernandez-Funez
May 6, 2011·Nature Reviews. Neuroscience·Chris I De ZeeuwSebastiaan K Koekkoek

❮ Previous
Next ❯

Citations

Nov 22, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kaori WatanabeTadashi Uemura
Jan 15, 2020·The Journal of Experimental Biology·Daniel P CaronBarry A Trimmer
Feb 20, 2018·Bio-protocol·Meike PetersenPeter Soba
Jun 28, 2021·Biophysical Journal·Rajshekhar BasakJonathon Howard

❮ Previous
Next ❯

Datasets Mentioned

BETA
GMR-Hid

Methods Mentioned

BETA
transgenic
FRET
PCR

Software Mentioned

LabVIEW
Clampex
MATLAB
Clampfit
iQ
Solis
ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Sheng li ke xue jin zhan [Progress in physiology]
Xiao-Yu Hou, Guang-Yi Zhang
Computational Intelligence and Neuroscience
Theodore W BergerNitish V Thakor
Science
M J Wayner, Y Oomura
© 2022 Meta ULC. All rights reserved