Neuronal responses support a role for orbitofrontal cortex in cognitive set reconfiguration

The European Journal of Neuroscience
Brianna J SleezerBenjamin Y Hayden

Abstract

We are often faced with the need to abandon no-longer beneficial rules and adopt new ones. This process, known as cognitive set reconfiguration, is a hallmark of executive control. Although cognitive functions like reconfiguration are most often associated with dorsal prefrontal structures, recent evidence suggests that the orbitofrontal cortex (OFC) may play an important role as well. We recorded the activity of OFC neurons while rhesus macaques performed an analogue of the Wisconsin Card Sorting Task that involved a trial and error stage. The OFC neurons demonstrated two types of switch-related activity, an early (switch-away) signal and a late (switch-to) signal, when the new task set was established. We also found a pattern of match modulation: a significant change in activity for the stimulus that matched the current perceptual rule (and would therefore be selected). These results extend our understanding of the executive functions of the OFC. They also allow us to directly compare the OFC with the complementary datasets we previously collected in the ventral (VS) and dorsal (DS) striatum. Although both effects are observed in all three areas, the timing of responses aligns the OFC more closely with DS than with VS.

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Citations

Dec 8, 2017·Journal of Neurophysiology·Tommy C BlanchardBenjamin Y Hayden
Jul 26, 2018·The European Journal of Neuroscience·Maria M DiehlDavid V Smith
Dec 6, 2019·The European Journal of Neuroscience·Pragathi Priyadharsini BalasubramaniBenjamin Y Hayden
Nov 9, 2019·PLoS Computational Biology·R Becket EbitzBenjamin Y Hayden
Apr 13, 2018·Frontiers in Computational Neuroscience·Pragathi P BalasubramaniBenjamin Y Hayden
Oct 12, 2019·F1000Research·Alik S WidgeBenjamin Y Hayden
Sep 16, 2020·Nature Reviews. Neuroscience·Farshad Alizadeh MansouriMark J Buckley
Dec 1, 2020·PLoS Biology·R Becket EbitzBenjamin Y Hayden
Apr 13, 2018·Brain and Neuroscience Advances·Benjamin Y Hayden, Rubén Moreno-Bote

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