Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus

Journal of Neural Transmission
Sayuri IshiwataToru Nishikawa

Abstract

In the hippocampus of mice lacking the gene for serine racemase (SR), a D-serine synthesizing enzyme, in the CaMKIIα-expressing neurons, we observed a significant decrease in the extracellular concentration of D-serine, a coagonist for the N-methyl-D-aspartate type glutamate receptor (NMDAR), and NMDAR hypofunction as revealed by diminished extracellular taurine concentrations after an intra-hippocampal NMDA infusion when compared to the wild type controls. Therefore, the neuronal SR could regulate the extracellular D-serine signaling responsible for NMDAR activation in the hippocampus.

References

Oct 24, 2003·Molecular and Cellular Neurosciences·Claude SchweizerBernhard Lüscher
Oct 24, 2007·Molecular Neurobiology·Herman Wolosker
Aug 7, 2008·Journal of Neuroscience Research·José A Rodríguez-NavarroJosé M Solís
Oct 14, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Toru Nishikawa
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dina RosenbergHerman Wolosker
Dec 30, 2014·Current Opinion in Pharmacology·Darrick T Balu, Joseph T Coyle

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Citations

May 17, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrea de BartolomeisFelice Iasevoli
Jun 21, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chantelle E TerrillionMikhail V Pletnikov
Mar 20, 2020·Neurochemical Research·Joseph T CoyleHerman Wolosker
Mar 29, 2019·Frontiers in Molecular Biosciences·Danielle L GrahamDavid B Berkowitz
Oct 14, 2017·Biological Psychiatry·Darrick T BaluJoseph T Coyle

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